2-Carboxy-1H-imidazole

2-Carboxy-1H-imidazole - Names and Identifiers

Name	1H-Imidazole-2-carboxylic acid
Synonyms	RARECHEM AL BE 0666 TIMTEC-BB SBB010014 2-Carboxy-1H-imidazole 2-Imidazolecarboxylic acid IMIDAZOLE-2-CARBOXYLIC ACID 1H-IMIDAZOLE-2-CARBOXYLIC ACID 1H-Imidazole-2-carboxylic acid 2-IMidazolecarboxylic Acid Hydrate
CAS	16042-25-4
EINECS	261-537-6
InChI	InChI=1/C4H4N2O2/c7-4(8)3-5-1-2-6-3/h1-2H,(H,5,6)(H,7,8)

2-Carboxy-1H-imidazole - Physico-chemical Properties

Molecular Formula	C4H4N2O2
Molar Mass	112.09
Density	1.524±0.06 g/cm3(Predicted)
Melting Point	198 °C
Boling Point	407.9±28.0 °C(Predicted)
Flash Point	200.5°C
Vapor Presure	2.19E-07mmHg at 25°C
Appearance	Crystallization
Color	White to Dark blue
Maximum wavelength(λmax)	['247nm(lit.)']
BRN	112615
pKa	1.44±0.10(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.616
MDL	MFCD00270816

2-Carboxy-1H-imidazole - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing.
Hazard Class	IRRITANT

2-Carboxy-1H-imidazole - Introduction

acid, chemical formula C4H4N2O2, is an organic compound. The following is a description of the nature, use, preparation and safety information of the Crystal acid:

Nature:
1. Appearance: acid is colorless to pale yellow crystalline powder.
2. Melting Point: about 191-192 ℃.
3. Solubility: acid soluble in water, ethanol and acetonitrile, insoluble in non-polar solvents.

Use:
1. Chemical Synthesis: acid can be used as an intermediate in organic synthesis and participate in a variety of organic synthesis reactions, such as oxidation, esterification, acylation, etc.
2. Drug application: acid and its derivatives can be used to synthesize drugs, anti-tumor agents, etc.
3. Catalyst: acid can be used as a precursor of amino acid catalyst for organic synthesis reaction.

Method:
The preparation method of acid is generally carried out in the following two steps:
1. First, imidazole is reacted with hydrogen cyanide to obtain imidazole-2-carbonitrile.
2. Then, react imidazole-2-carbonitrile with acid (such as hydrochloric acid or sulfuric acid, etc.) to obtain acid.

Safety Information:
1. acid has low toxicity to human body under normal use conditions and is not easy to absorb.
2. During use, avoid contact with skin and eyes, and take appropriate protective measures when necessary.
3. When storing and handling acid, pay attention to moisture-proof, fire-proof, and avoid contact with oxidants.
4. If you accidentally touch or eat, you should seek medical attention immediately and bring the packaging or safety data sheet.

Last Update：2024-04-09 21:01:54