2-Chloro-3,4-pyridinediamine

2-Chloro-3,4-pyridinediamine - Names and Identifiers

Name	2-Chloro-3,4-diaminopyridine
Synonyms	NSC 143160 2-Chloropyridin-3,4-diamine 2-Chloro-3,4-diaminopyridine 2-chloropyridine-3,4-diamine 2-Chloro-3,4-pyridinediam... 3,4-Diamino-2-chloropyridine 2-Chloro-3,4-pyridinediamine (4-amino-2-chloro-3-pyridyl)amine 2-chloropyridine-3,4-diaMinehydrochloride
CAS	39217-08-8
InChI	InChI=1/C5H6ClN3/c6-5-4(8)3(7)1-2-9-5/h1-2H,8H2,(H2,7,9)

2-Chloro-3,4-pyridinediamine - Physico-chemical Properties

Molecular Formula	C5H6ClN3
Molar Mass	143.57
Density	1.447±0.06 g/cm3(Predicted)
Melting Point	158-163℃
Boling Point	381.3±37.0 °C(Predicted)
Flash Point	184.427°C
Vapor Presure	0mmHg at 25°C
pKa	4.79±0.42(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.685

2-Chloro-3,4-pyridinediamine - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R36 - Irritating to the eyes R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	2811
WGK Germany	3
HS Code	29333990
Hazard Class	6.1
Packing Group	Ⅲ

2-Chloro-3,4-pyridinediamine - Introduction

2-Chloro-3,4-diaminopyridine is an organic compound with the chemical formula C5H5ClN3. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 2-Chloro-3,4-diaminopyridine is a colorless crystalline solid.
-Solubility: It is soluble in water and some organic solvents, such as methanol and ethanol.
-Melting point: Its melting point is about 243-244°C.
-Stability: It is relatively stable at room temperature.

Use:
-Pharmaceutical field: 2-Chloro-3,4-diaminopyridine can be used as an intermediate for drugs. It plays an important role in some drugs, such as the treatment of leukemia and other malignant tumors.
-Organic synthesis: It can be used in organic synthesis, such as the preparation of catalysts, the synthesis of nucleotide derivatives, etc.

Preparation Method:
2-Chloro-3,4-diaminopyridine can be prepared by the following method:
1. Pyridine reacts with trichlorophosphorus cyanide to generate 2-chloropyridine;
2. 2-Chloropyridine reacts with ammonia to produce 2-Chloro-3,4-diaminopyridine.

Safety Information:
- 2-Chloro-3,4-diaminopyridine is an organic compound with certain toxicity. During handling and storage, it is necessary to comply with relevant safety operating standards.
-Avoid inhalation, ingestion or contact with skin and eyes.
-If inhalation, ingestion or skin contact occurs, rinse with water and seek medical help.
-When storing and handling 2-Chloro-3,4-diaminopyridine, avoid mixing with oxidants, strong acids and strong bases to prevent dangerous reactions.

Please note that in the process of using 2-Chloro-3,4-diaminopyridine, you should operate carefully according to the specific situation and abide by the laboratory's safe operation regulations.

Last Update：2024-04-09 15:17:58