2-Chloro-3-hydroxy-6-methylpyridine

2-Chloro-3-hydroxy-6-methylpyridine - Names and Identifiers

Name	2-chloro-6-methylpyridin-3-ol
Synonyms	2-chloro-6-methylpyridin-3-ol 2-CHLORO-3-HYDROXY-6-PICOLINE 3-Pyridinol, 2-chloro-6-methyl- 2-Chloro-3-hydroxy-6-methylpyridine
CAS	35680-24-1
EINECS	252-675-8
InChI	InChI=1/C6H6ClNO/c1-4-2-3-5(9)6(7)8-4/h2-3,9H,1H3

2-Chloro-3-hydroxy-6-methylpyridine - Physico-chemical Properties

Molecular Formula	C6H6ClNO
Molar Mass	143.57
Density	1.313g/cm³
Boling Point	307.3°C at 760 mmHg
Flash Point	139.7°C
Vapor Presure	0.000403mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.571

2-Chloro-3-hydroxy-6-methylpyridine - Introduction

It is an organic compound with the chemical formula C7H8ClNO. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless to pale yellow solid.
-Solubility: Its solubility in water is low, but it can be dissolved in organic solvents such as methanol, ethanol and dichloromethane.
-Melting point: Its melting point range is generally between 95-99 ℃.
-Stability: The compound is relatively stable to light and air, but may react under strong acid and strong alkali conditions.

Use:
-It can be used as an important intermediate in organic synthesis.
-It is often used as a starting material for the preparation of biologically active compounds, such as drugs, pesticides and dyes.
-In addition, it can also be used as a reagent in fine chemicals and laboratory research.

Preparation Method:
-Usually, it can be synthesized by the following steps:
(1) 2-chloro-6-methylpyridine reacts with potassium bicarbonate under alkaline conditions to generate the corresponding chloropyridine compounds.
(2) The chloropyridine is then reacted with formaldehyde under basic conditions to obtain a 2-chloro-6-methylpyridine-3-aldehyde compound.
(3) Finally, 2-chloro-6-methylpyridine-3-aldehyde is reduced to the corresponding alcohol by reduction reaction or acid catalysis.

Safety Information: If suspended or dissolved, it may cause irritation to the skin, eyes and respiratory tract, so wear appropriate personal protective equipment, such as gloves and glasses.
-When handling this compound, avoid inhaling dust or aerosol forms.
-When storing, it should be placed in a sealed container, away from high temperature and fire sources.
-Before using or handling, please carefully read and follow the relevant safety guidelines and operating procedures.

Last Update：2024-04-09 21:00:56