2-Chloro-3-methoxypyridine
2-Chloro-3-methoxypyridine
CAS: 52605-96-6
Molecular Formula: C6H6ClNO
2-Chloro-3-methoxypyridine - Names and Identifiers
| Name | 2-Chloro-3-methoxypyridine |
| Synonyms | 2-CHLORO-3-METHOXYPYRIDINE 2-Chloro-3-methoxypyridine Pyridine, 2-chloro-3-Methoxy- |
| CAS | 52605-96-6 |
| EINECS | 258-039-6 |
| InChI | InChI=1/C6H6ClNO/c1-9-5-3-2-4-8-6(5)7/h2-4H,1H3 |
2-Chloro-3-methoxypyridine - Physico-chemical Properties
| Molecular Formula | C6H6ClNO |
| Molar Mass | 143.57 |
| Density | 1.210±0.06 g/cm3(Predicted) |
| Melting Point | 90-92°C |
| Boling Point | 210.6±20.0 °C(Predicted) |
| Flash Point | 81.2°C |
| Water Solubility | Insoluble in water. |
| Vapor Presure | 0.276mmHg at 25°C |
| BRN | 115568 |
| pKa | -0.51±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.517 |
| MDL | MFCD03426022 |
2-Chloro-3-methoxypyridine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves. |
| HS Code | 29333990 |
2-Chloro-3-methoxypyridine - Introduction
2-Chloro-3-methoxypyridine(2-Chloro-3-methoxypyridine) is an organic compound with the chemical formula C6H6ClNO. It is a colorless liquid with a pungent odor. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless liquid
-Molecular weight: 159.57g/mol
-Melting Point: Unknown
-Boiling point: 203-205 ℃
-Density: 1.233g/cm3
-Solubility: Soluble in ethanol, ether and chlorinated hydrocarbons
Use:
- 2-Chloro-3-methoxypyridine is commonly used as an intermediate in organic synthesis reactions.
-In the field of medicine, it can be used to synthesize pharmaceutical intermediates and active drugs.
Preparation Method:
The preparation method of 2-Chloro-3-methoxypyridine is mainly obtained by the protonation and chlorination reaction of pyridine. Specific synthetic pathways can be:
1. reacting pyridine with hydrogen chloride to obtain chloropyridine;
2. methanol and sodium hydroxide are added to the chloropyridine solution to generate a product, which is purified to obtain 2-Chloro-3-methoxypyridine.
Safety Information:
- 2-Chloro-3-methoxypyridine is an organic compound and is irritating. Direct contact with skin and eyes should be avoided.
-During handling or storage, appropriate protective measures should be taken and personal protective equipment such as gloves and goggles should be worn.
-Avoid inhaling its vapor or solution during use and keep it well ventilated.
-Avoid contact with strong oxidants, strong acids and other substances to prevent dangerous reactions.
-After use or disposal, the remaining chemicals should be disposed of safely and in compliance with relevant environmental safety regulations.
Nature:
-Appearance: colorless liquid
-Molecular weight: 159.57g/mol
-Melting Point: Unknown
-Boiling point: 203-205 ℃
-Density: 1.233g/cm3
-Solubility: Soluble in ethanol, ether and chlorinated hydrocarbons
Use:
- 2-Chloro-3-methoxypyridine is commonly used as an intermediate in organic synthesis reactions.
-In the field of medicine, it can be used to synthesize pharmaceutical intermediates and active drugs.
Preparation Method:
The preparation method of 2-Chloro-3-methoxypyridine is mainly obtained by the protonation and chlorination reaction of pyridine. Specific synthetic pathways can be:
1. reacting pyridine with hydrogen chloride to obtain chloropyridine;
2. methanol and sodium hydroxide are added to the chloropyridine solution to generate a product, which is purified to obtain 2-Chloro-3-methoxypyridine.
Safety Information:
- 2-Chloro-3-methoxypyridine is an organic compound and is irritating. Direct contact with skin and eyes should be avoided.
-During handling or storage, appropriate protective measures should be taken and personal protective equipment such as gloves and goggles should be worn.
-Avoid inhaling its vapor or solution during use and keep it well ventilated.
-Avoid contact with strong oxidants, strong acids and other substances to prevent dangerous reactions.
-After use or disposal, the remaining chemicals should be disposed of safely and in compliance with relevant environmental safety regulations.
Last Update：2024-04-09 02:00:46
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