2-Chloro-4-fluoro-1H-benzimidazole

2-Chloro-4-fluoro-1H-benzimidazole - Names and Identifiers

Name	1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
Synonyms	2-Chloro-4-fluorobenzimidazole 2-Chloro-4-fluoro-1H-benzimidazole 1H-BENZIMIDAZOLE, 2-CHLORO-4-FLUORO- 1H-Benzimidazole, 2-chloro-7-fluoro- 2-chloro-4-fluoro-1H-1,3-benzodiazole 2-Chloro-4-fluoro-1H-benzo[d]imidazole 2-Chloro-7-fluoro-1H-benzo[d]imidazole 1H-Benzimidazole,2-chloro-4-fluoro-(9CI)
CAS	256519-11-6

2-Chloro-4-fluoro-1H-benzimidazole - Physico-chemical Properties

Molecular Formula	C7H4ClFN2
Molar Mass	170.57
Density	1.533±0.06 g/cm3(Predicted)
Boling Point	332.9±34.0 °C(Predicted)
pKa	7.60±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

2-Chloro-4-fluoro-1H-benzimidazole - Reference Information

Application

2-chloro-4-fluoro-(9CI)-1H-benzimidazole can be used to prepare 4-fluoro-n-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonamido) cyclopropyl] pyrimidin-2-yl}-1H-benzimidazole-2-amine and 4-fluoro-n-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonamido) cyclopropyl] pyrimidin-2-yl}-1H-benzimidazol-2-amine. Both compounds are useful in the treatment of proliferative diseases (such as cancer), especially in the treatment of diseases caused by ataxia-telangiectasia mutation and RAD-3 associated protein kinase inhibitors (commonly known as ATR). It has important uses in mediated diseases.

Use

2-chloro-4-fluoro-(9CI)-1H-benzimidazole is a pharmaceutical intermediate, 4-fluoro-1h-benzo [d] imidazol-2 (3H)-one can be prepared from 3-fluorobenzene-1, 2-diamine and then obtained by chlorination. It has been reported in the literature to be useful in the preparation of ATR kinase inhibitors.

Last Update：2024-04-09 21:32:10