2-Chloro-5-(methoxycarbonyl)pyrazine
Methyl-5-chloropyrazine-2-carboxylate
CAS: 33332-25-1;105786-34-3
Molecular Formula: C6H5ClN2O2
2-Chloro-5-(methoxycarbonyl)pyrazine - Names and Identifiers
2-Chloro-5-(methoxycarbonyl)pyrazine - Physico-chemical Properties
| Molecular Formula | C6H5ClN2O2 |
| Molar Mass | 172.57 |
| Density | 1.372±0.06 g/cm3(Predicted) |
| Melting Point | 89-90 °C(Solv: ligroine (8032-32-4)) |
| Boling Point | 242.8±35.0 °C(Predicted) |
| Flash Point | 117.146°C |
| Vapor Presure | 0.018mmHg at 25°C |
| Appearance | Solid |
| pKa | -4.54±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.525 |
| MDL | MFCD01632102 |
| Physical and Chemical Properties | Methyl 5-chloropyrazine-2-carboxylate has a melting point of 89-90°C, a boiling point of 242.8±35.0°C(Predicted), a density of 1.372±0.06g/cm3(Predicted), and a coefficient of acidity (pKa). Yes -4.54±0.10(Predicted). |
2-Chloro-5-(methoxycarbonyl)pyrazine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
2-Chloro-5-(methoxycarbonyl)pyrazine - Introduction
Methyl-5-chloropyrazine-2-carboxylate is an organic compound with the chemical formula C7H5ClN2O2. The following is a detailed description of its nature, use, preparation and safety information:
Nature:
-Appearance: The Methyl-5-chloropyrazine-2-carboxylate is in the form of white crystals or crystalline powder.
-Melting point: about 54-57 ℃.
-Boiling point: About 253-254 ℃.
-Solubility: Methyl-5-chloropyrazine-2-carboxylate is soluble in some organic solvents, such as ethanol and dichloromethane.
-Stability: The compound is relatively stable under regular storage conditions.
Use:
Methyl-5-chloropyrazine-2-carboxylate has certain application value in chemical synthesis and pharmaceutical field.
-Chemical synthesis: It can be used as raw materials or intermediates in organic synthesis for the synthesis of other compounds, such as pesticides, dyes and pharmaceutical intermediates.
-Pharmaceutical field: Methyl-5-chloropyrazine-2-carboxylate acts as an intermediate in the synthesis of certain drugs and has biological activities such as antibacterial, sedative and anti-inflammatory.
Method:
Methyl-5-chloropyrazine-2-carboxylate can generally be prepared by the following steps:
1. React 5-chloropyrazine with Formic Anhydride to generate 5-chloropyrazine -2-Formic Anhydride.
2. React 5-chloropyrazine-2-carboxylic anhydride with methanol to generate the target product Methyl-5-chloropyrazine-2-carboxylate.
This is a simple chemical synthesis route, but the specific synthesis method may vary according to different research needs.
Safety Information:
-The Methyl-5-chloropyrazine-2-carboxylate is generally safer under correct operation, but the following safety measures should still be paid attention:
-Contact: Avoid direct contact with skin and eyes. Wear personal protective equipment such as laboratory gloves and goggles when working.
-Inhalation: An effective ventilation system should be equipped during operation to ensure good indoor air circulation. Avoid inhaling dust or vapors.
-edible: Methyl-5-chloropyrazine-2-carboxylate for chemicals, is strictly prohibited.
-Storage: Store the compound in a dry, cool, ventilated place, away from fire and combustibles.
Please note that the above information is for reference only, and you should use caution and follow appropriate laboratory safety regulations when using this compound.
Nature:
-Appearance: The Methyl-5-chloropyrazine-2-carboxylate is in the form of white crystals or crystalline powder.
-Melting point: about 54-57 ℃.
-Boiling point: About 253-254 ℃.
-Solubility: Methyl-5-chloropyrazine-2-carboxylate is soluble in some organic solvents, such as ethanol and dichloromethane.
-Stability: The compound is relatively stable under regular storage conditions.
Use:
Methyl-5-chloropyrazine-2-carboxylate has certain application value in chemical synthesis and pharmaceutical field.
-Chemical synthesis: It can be used as raw materials or intermediates in organic synthesis for the synthesis of other compounds, such as pesticides, dyes and pharmaceutical intermediates.
-Pharmaceutical field: Methyl-5-chloropyrazine-2-carboxylate acts as an intermediate in the synthesis of certain drugs and has biological activities such as antibacterial, sedative and anti-inflammatory.
Method:
Methyl-5-chloropyrazine-2-carboxylate can generally be prepared by the following steps:
1. React 5-chloropyrazine with Formic Anhydride to generate 5-chloropyrazine -2-Formic Anhydride.
2. React 5-chloropyrazine-2-carboxylic anhydride with methanol to generate the target product Methyl-5-chloropyrazine-2-carboxylate.
This is a simple chemical synthesis route, but the specific synthesis method may vary according to different research needs.
Safety Information:
-The Methyl-5-chloropyrazine-2-carboxylate is generally safer under correct operation, but the following safety measures should still be paid attention:
-Contact: Avoid direct contact with skin and eyes. Wear personal protective equipment such as laboratory gloves and goggles when working.
-Inhalation: An effective ventilation system should be equipped during operation to ensure good indoor air circulation. Avoid inhaling dust or vapors.
-edible: Methyl-5-chloropyrazine-2-carboxylate for chemicals, is strictly prohibited.
-Storage: Store the compound in a dry, cool, ventilated place, away from fire and combustibles.
Please note that the above information is for reference only, and you should use caution and follow appropriate laboratory safety regulations when using this compound.
Last Update：2024-04-09 19:05:49
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