2-Chloro-5-fluoro-3-methylpyridine
2-Chloro-5-fluoro-3-methylpyridine
CAS: 38186-84-4
Molecular Formula: C6H5ClFN
2-Chloro-5-fluoro-3-methylpyridine - Names and Identifiers
2-Chloro-5-fluoro-3-methylpyridine - Physico-chemical Properties
| Molecular Formula | C6H5ClFN |
| Molar Mass | 145.56 |
| Density | 1.264±0.06 g/cm3(Predicted) |
| Melting Point | 41.0 to 45.0 °C |
| Boling Point | 177.9±35.0 °C(Predicted) |
| Flash Point | 61.409°C |
| Vapor Presure | 1.369mmHg at 25°C |
| pKa | -1.59±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.504 |
2-Chloro-5-fluoro-3-methylpyridine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Note | Irritant |
2-Chloro-5-fluoro-3-methylpyridine - Introduction
It is an organic compound whose chemical formula is C6H5ClFN. Here is the relevant information about the compound:
Nature:
-Appearance: Colorless liquid or white crystalline solid.
-Melting point: about 5-6°C.
-Boiling point: about 190°C.
-Density: about 1.31g/cm³.
-Solubility: Soluble in most organic solvents, such as alcohols and ethers.
Use:
-is often used as an intermediate in the synthesis of other compounds. For example, it can be used in the synthesis of pesticides, pharmaceuticals, dyes and other organic compounds.
-In addition, it can also be used as a ligand to produce a protective film on the metal surface.
Preparation Method:
It can be synthesized by a variety of methods, one of which is commonly used to catalyze the fluorination and chlorination of pyridine by spinel catalysts. Specific methods are as follows:
1. pyridine is reacted with hydrofluoric acid to obtain the fluorinated product of pyridine.
2. In the presence of a chlorinating agent, the fluorinated product is reacted with a chlorinating agent to generate 2-chloro-3-fluoropyridine.
3. Finally, 2-chloro-3-fluoropyridine is reacted with a methylating reagent to obtain fluorene.
Safety Information:
-is a chemical that needs to be handled and stored properly.
-Wear appropriate personal protective equipment such as masks, gloves and goggles during handling and handling.
-Avoid inhalation, ingestion or contact with skin and eyes.
-In case of accidental contact, immediately flush the affected area with plenty of water and seek medical help.
-When storing and using, should follow the relevant regulations and operating guidelines.
Nature:
-Appearance: Colorless liquid or white crystalline solid.
-Melting point: about 5-6°C.
-Boiling point: about 190°C.
-Density: about 1.31g/cm³.
-Solubility: Soluble in most organic solvents, such as alcohols and ethers.
Use:
-is often used as an intermediate in the synthesis of other compounds. For example, it can be used in the synthesis of pesticides, pharmaceuticals, dyes and other organic compounds.
-In addition, it can also be used as a ligand to produce a protective film on the metal surface.
Preparation Method:
It can be synthesized by a variety of methods, one of which is commonly used to catalyze the fluorination and chlorination of pyridine by spinel catalysts. Specific methods are as follows:
1. pyridine is reacted with hydrofluoric acid to obtain the fluorinated product of pyridine.
2. In the presence of a chlorinating agent, the fluorinated product is reacted with a chlorinating agent to generate 2-chloro-3-fluoropyridine.
3. Finally, 2-chloro-3-fluoropyridine is reacted with a methylating reagent to obtain fluorene.
Safety Information:
-is a chemical that needs to be handled and stored properly.
-Wear appropriate personal protective equipment such as masks, gloves and goggles during handling and handling.
-Avoid inhalation, ingestion or contact with skin and eyes.
-In case of accidental contact, immediately flush the affected area with plenty of water and seek medical help.
-When storing and using, should follow the relevant regulations and operating guidelines.
Last Update：2024-04-09 21:00:56
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