2-Chloro-5-fluoro-3-methylpyridine

2-Chloro-5-fluoro-3-methylpyridine - Names and Identifiers

Name	2-Chloro-5-fluoro-3-methylpyridine
Synonyms	2-Chloro-5-fluoro-3-picoline 2-CHLORO-5-FLUORO-3-PICOLINE 2-Chloro-5-fluoroa3-picoline 2-Chloro-3-methy-5-fluorolpyridine 2-Chloro-3-Methyl-5-fluoropyridine 2-CHLORO-3-METHYL-5-FLUOROPYRIDINE 2-Chloro-5-fluoro-3-methylpyridine 2-CHLORO-5-FLUORO-3-METHYLPYRIDINE Pyridine, 2-chloro-5-fluoro-3-methyl- 2-Chloro-5-fluoro-3-methylpyridine 2-Chloro-5-fluoro-3-picoline
CAS	38186-84-4
EINECS	627-638-8
InChI	InChI=1/C6H5ClFN/c1-4-2-5(8)3-9-6(4)7/h2-3H,1H3

2-Chloro-5-fluoro-3-methylpyridine - Physico-chemical Properties

Molecular Formula	C6H5ClFN
Molar Mass	145.56
Density	1.264±0.06 g/cm3(Predicted)
Melting Point	41.0 to 45.0 °C
Boling Point	177.9±35.0 °C(Predicted)
Flash Point	61.409°C
Vapor Presure	1.369mmHg at 25°C
pKa	-1.59±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.504

2-Chloro-5-fluoro-3-methylpyridine - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note	Irritant

2-Chloro-5-fluoro-3-methylpyridine - Introduction

It is an organic compound whose chemical formula is C6H5ClFN. Here is the relevant information about the compound:

Nature:
-Appearance: Colorless liquid or white crystalline solid.
-Melting point: about 5-6°C.
-Boiling point: about 190°C.
-Density: about 1.31g/cm³.
-Solubility: Soluble in most organic solvents, such as alcohols and ethers.

Use:
-is often used as an intermediate in the synthesis of other compounds. For example, it can be used in the synthesis of pesticides, pharmaceuticals, dyes and other organic compounds.
-In addition, it can also be used as a ligand to produce a protective film on the metal surface.

Preparation Method:
It can be synthesized by a variety of methods, one of which is commonly used to catalyze the fluorination and chlorination of pyridine by spinel catalysts. Specific methods are as follows:
1. pyridine is reacted with hydrofluoric acid to obtain the fluorinated product of pyridine.
2. In the presence of a chlorinating agent, the fluorinated product is reacted with a chlorinating agent to generate 2-chloro-3-fluoropyridine.
3. Finally, 2-chloro-3-fluoropyridine is reacted with a methylating reagent to obtain fluorene.

Safety Information:
-is a chemical that needs to be handled and stored properly.
-Wear appropriate personal protective equipment such as masks, gloves and goggles during handling and handling.
-Avoid inhalation, ingestion or contact with skin and eyes.
-In case of accidental contact, immediately flush the affected area with plenty of water and seek medical help.
-When storing and using, should follow the relevant regulations and operating guidelines.

Last Update：2024-04-09 21:00:56