2-Chloro-5-fluoronicotinaldehyde

2-Chloro-5-fluoronicotinaldehyde - Names and Identifiers

Name	2-chloro-5-fluoro-pyridine-3-carbaldehyde
Synonyms	2-Chloro-5-fluoronicotinaldehyde 2-Chloro-5-fluoro-3-formylpyridine 2-Chloro-5-fluoro-3-pyridinecarbaldehyde 2-Choro-5-fluoropyridin-ylcarboxaldehyde 2-Chloro-5-fluoro-pyridine-3-carbaldehyde 2-CHLORO-5-FLUORO-PYRIDINE-3-CARBALDEHYDE 2-chloro-5-fluoro-pyridine-3-carbaldehyde 2-Chloro-5-fluoropyridine-3-carboxaldehyde 2-CHLORO-5-FLUORO-3-PYRIDINECARBOXALDEHYDE 3-Pyridinecarboxaldehyde, 2-chloro-5-fluoro- 3-pyridinecarboxaldehyde, 2-chloro-5-fluoro-
CAS	851484-95-2
InChI	InChI=1/C6H3ClFNO/c7-6-4(3-10)1-5(8)2-9-6/h1-3H

2-Chloro-5-fluoronicotinaldehyde - Physico-chemical Properties

Molecular Formula	C6H3ClFNO
Molar Mass	159.55
Density	1.444±0.06 g/cm3(Predicted)
Boling Point	224.4±35.0 °C(Predicted)
Flash Point	89.501°C
Vapor Presure	0.091mmHg at 25°C
pKa	-3.70±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.565

2-Chloro-5-fluoronicotinaldehyde - Risk and Safety

Hazard Class

IRRITANT

2-Chloro-5-fluoronicotinaldehyde - Introduction

It is an organic compound with the chemical formula C7H4ClFNO. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: It is a colorless to light yellow liquid.
-Solubility: It is soluble in organic solvents such as dimethylformamide and dichloromethane, and insoluble in water.
-Melting point and boiling point: Its melting point is -25 ℃, and its boiling point is about 189 ℃.
-Density: Its density is about 1.41g/cm³.

Use:
-is widely used in organic synthesis. As an intermediate in organic synthesis, it has an important position in the pesticide and pharmaceutical industries.
-It can be used to synthesize specific pyridine derivatives, and as a raw material to participate in a variety of reactions, such as Grignard reagent reaction, suspension leaching reaction, aldehyde ketone reaction, etc.

Preparation Method:
-is prepared by reacting pyridine with trichloroacetyl chloride (or other electrophiles). A common method is to react pyridine with trichloroacetyl chloride in dimethylformamide solution at room temperature to give the desired product. After completion of the reaction, a product is obtained by distillation or the like.

Safety Information:
-³ is an organic compound that should be used properly in a laboratory environment and pay attention to safe operation.
-It may cause irritation and damage to the eyes, skin, respiratory and digestive systems. Appropriate personal protective equipment such as gloves, goggles and protective clothing should be used during use or contact.
-Avoid mixing with chemicals such as oxidants and strong acids during handling and storage.
-If the compound is accidentally inhaled, touched or ingested, seek medical advice immediately and provide the safety data sheet and packaging for your doctor's reference.

Please note that in actual use, you should follow the relevant safety operation specifications and refer to the specific safety data provided by the laboratory.

Last Update：2024-04-09 15:18:00