2-Chloro-5-iodonicotinonitrile

2-Chloro-5-iodonicotinonitrile - Names and Identifiers

Name	2-Chloro-5-iodonicotinonitrile
Synonyms	2-Chloro-5-iodonicotinonitrile 2-Chloro-3-cyano-5-iodopyridine 2-chloro-5-iodo-3-pyridinecarbonitrile 2-CHLORO-5-IODOPYRIDINE-3-CARBONITRILE 2-Chloro-5-iodo-3-pyridinecarbonitrile 3-Pyridinecarbonitrile, 2-chloro-5-iodo-
CAS	766515-34-8
EINECS	1312995-182-4

2-Chloro-5-iodonicotinonitrile - Physico-chemical Properties

Molecular Formula	C6H2ClIN2
Molar Mass	264.45
Density	2.13
Storage Condition	2-8°C(protect from light)

2-Chloro-5-iodonicotinonitrile - Reference Information

Use

2-chloro-5-iodo-3-pyridinecarbonitrile is useful as an intermediate for the synthesis of pharmaceuticals.

preparation

0.7ml(329mmol) of phosphorus oxychloride and 6 drops of sulfuric acid at 30.7 °c were added to 9g(6.6mmol). 2-hydroxy-5-iodonicotinonitrile. The reaction mixture was heated at 110 °c for 5 hours and then at room temperature overnight. The reaction mixture was poured into a beaker containing ice and a small amount of water to form a precipitate. The mixture was gradually allowed to return to room temperature, then filtered and washed with water. The solid was dried to give 2-chloro-5-iodo-3-pyridinecarbonitrile.

Last Update：2024-04-10 22:29:15