2-Chloro-5-methyl-3-nitropyridine
2-Chloro-5-methyl-3-nitropyridine
CAS: 23056-40-8
Molecular Formula: C6H5ClN2O2
2-Chloro-5-methyl-3-nitropyridine - Names and Identifiers
| Name | 2-Chloro-5-methyl-3-nitropyridine |
| Synonyms | 2-CHLORO-3-NITRO-5-PICOLINE 6-Chloro-5-nitro-3-picoline 6-CHLORO-5-NITRO-3-PICOLINE 2-CHLORO-5-METHYL-3-NITROPYRIDINE 2-CHLORO-3-NITRO-5-METHYLPYRIDINE 2-Chloro-5-methyl-3-nitropyridine 2-Chloro-3,5-dimethyl-4-methoxypyridine 2-CHLORO-3-NITRO-5-PICOLINE (2-CHLORO-5-METHYL-3-NITROPYRIDINE) |
| CAS | 23056-40-8 |
| EINECS | 624-905-0 |
| InChI | InChI=1/C6H5ClN2O2/c1-4-2-5(9(10)11)6(7)8-3-4/h2-3H,1H3 |
2-Chloro-5-methyl-3-nitropyridine - Physico-chemical Properties
| Molecular Formula | C6H5ClN2O2 |
| Molar Mass | 172.57 |
| Density | 1.406±0.06 g/cm3(Predicted) |
| Melting Point | 45-50 °C |
| Boling Point | 290.8±35.0 °C(Predicted) |
| Flash Point | 129.7°C |
| Vapor Presure | 0.00353mmHg at 25°C |
| Appearance | Solid |
| BRN | 138198 |
| pKa | -2.20±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Hygroscopic |
| Refractive Index | 1.575 |
| MDL | MFCD02070020 |
2-Chloro-5-methyl-3-nitropyridine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R21/22 - Harmful in contact with skin and if swallowed. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Harmful |
| Hazard Class | 6.1 |
| Packing Group | III |
2-Chloro-5-methyl-3-nitropyridine - Reference Information
| Application | 2-chloro-5-methyl-3-nitropyridine is an organic intermediate, which can be obtained by chlorination of 5-methyl-3-nitropyridine -2(1H)-ketone, and the chlorination reagent can be selected from phosphorus oxychloride, it can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes. |
| preparation | 5-methyl -3-nitro-pyridin-2-ol (5g,32.4mmol) and benzyl trimethyl ammonium chloride (3.01g,16.2mmol) are dissolved in acetonitrile, and phosphorus chloride (9.0ml,97.2mmol) is added to it, and stirring at 80 ℃ for 6 hours. The reaction mixture is cooled and poured into ice water to quench the reaction, and extracted with dichloromethane. The combined organic layer is washed with saturated salt solution, dried with anhydrous sodium sulfate (Na2SO4), filtered and distilled under reduced pressure. The residue was purified by column chromatography on silica eluted with dichloromethane solvent. The product-containing fraction was collected and evaporated to obtain a yellow solid 2-chloro -5-methyl -3-nitro-pyridine (5.39g,97%). |
Last Update：2024-04-10 22:29:15
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View History
2-Chloro-5-methyl-3-nitropyridine
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17302-11-3
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