2-Chloro-5-nitrobenzophenone
2-Chloro-5-nitrobenzophenone
CAS: 34052-37-4
Molecular Formula: C13H8ClNO3
2-Chloro-5-nitrobenzophenone - Names and Identifiers
| Name | 2-Chloro-5-nitrobenzophenone |
| Synonyms | LABOTEST-BB LT00159800 2-CHLORO-5-NITROBENZOPHENONE 2-Chloro-5-nitrobenzophenone 5-NITRO-2-CHLOROBENZOPHENONE 2 Chloro 5 Nitro benzophenone (2-chloro-5-nitrophenyl)(phenyl)Methanone (2-chloro-5-nitrophenyl)(phenyl)methanone Methanone, (2-chloro-5-nitrophenyl)phenyl- 2-[4-[3-(2-chloro-6H-benzo[c][1,5]benzoxazepin-11-yl)propyl]-1-piperazinyl]ethanol |
| CAS | 34052-37-4 |
| EINECS | 251-811-3 |
| InChI | InChI=1/C13H8ClNO3/c14-12-7-6-10(15(17)18)8-11(12)13(16)9-4-2-1-3-5-9/h1-8H |
2-Chloro-5-nitrobenzophenone - Physico-chemical Properties
| Molecular Formula | C13H8ClNO3 |
| Molar Mass | 261.66 |
| Density | 1.3227 (rough estimate) |
| Melting Point | 83-85°C(lit.) |
| Boling Point | 235°C (rough estimate) |
| Flash Point | 200.4°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 7.42E-07mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Orange to Green |
| Storage Condition | Room Temprature |
| Refractive Index | 1.5200 (estimate) |
| MDL | MFCD00007295 |
| Physical and Chemical Properties | Light yellow powder |
2-Chloro-5-nitrobenzophenone - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| HS Code | 29147000 |
2-Chloro-5-nitrobenzophenone - Reference Information
| Overview | 2-chloro-5-nitrobenzophenone is a ketone organic substance and can be used as an intermediate in pharmaceutical synthesis. |
| Preparation | A preparation method of 2-chloro-5-nitrobenzophenone: Add 1.0 mol2-chloro-5-nitrobenzoyl chloride (1.0mol), 0.5mol aluminum trichloride, 1mol zinc chloride and 3000ml dichloromethane to a four-mouth bottle equipped with an electric stirrer and a thermometer, and introduce nitrogen to protect it, the temperature of the reaction solution is reduced to -20 ~-15 ℃, and then 1.2mol of benzene is added dropwise. During the dropwise process, the temperature of the reaction solution is controlled to 20 ~-15 ℃. After the dropwise addition, the temperature is kept and stirred for 2 hours. After the reaction, the reaction solution was slowly poured into 2000 ml0.5mol/L hydrochloric acid (cooled to 0~10 ℃), kept at 0~10 ℃ and stirred for 5~10min, and the aqueous phase was extracted with 500ml dichloroethane. Combine the organic phase, wash once with 500ml of saturated sodium carbonate solution, wash again with 500ml of water three times to neutral, add 200g of anhydrous magnesium sulfate to dry, and evaporate most of the dichloromethane. The residual liquid was added with 500ml of mixed solution of ethyl acetate and petroleum ether with a volume ratio of 2:1 to crystallize to obtain 2-chloro-5-nitrobenzophenone. The product was dried to 248.5g with 95% yield and 99.5% purity. |
| use | as a pharmaceutical intermediate |
Last Update：2024-04-09 15:16:50
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