2-Chloro-6-hydroxybenzoni...
2-chloro-6-hydroxybenzonitrile
CAS: 89999-90-6
Molecular Formula: C7H4ClNO
2-Chloro-6-hydroxybenzoni... - Names and Identifiers
| Name | 2-chloro-6-hydroxybenzonitrile |
| Synonyms | 3-Chloro-2-cyanophenol 2-Chloro-6-hydroxybenzoni... 2-CHLORO-6-HYDROXYBENZONITRILE 2-Hydroxy-6-chlorobenzonitrile 2-chloro-6-hydroxybenzonitrile benzonitrile, 2-chloro-6-hydroxy- Benzonitrile, 2-chloro-6-hydroxy- |
| CAS | 89999-90-6 |
| InChI | InChI=1/C7H4ClNO/c8-6-2-1-3-7(10)5(6)4-9/h1-3,10H |
2-Chloro-6-hydroxybenzoni... - Physico-chemical Properties
| Molecular Formula | C7H4ClNO |
| Molar Mass | 153.57 |
| Density | 1.41 |
| Melting Point | 162-164℃ |
| Boling Point | 296.2±25.0 °C(Predicted) |
| Flash Point | 133°C |
| Vapor Presure | 0.000823mmHg at 25°C |
| pKa | 6.20±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.611 |
2-Chloro-6-hydroxybenzoni... - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN2811 |
2-Chloro-6-hydroxybenzoni... - Introduction
It is an organic compound with the chemical formula of C7H4ClNO. In the chemical structure, there is a chlorine atom and a hydroxyl group substituted for the benzene ring, and there is a nitrile group attached to the benzene ring. The compound has the solid nature of colorless or white crystals.
It is mainly used in the field of organic synthesis and medicine. It can be used as a pharmaceutical intermediate for the synthesis of other compounds, such as antibiotics, anti-tumor drugs, fungicides, etc. In addition, it can also be applied to pesticides, dyes and other fields.
The preparation can be obtained by the reaction of phenol and cuprous chloride. First, phenol is methylated with a methylenating agent under alkaline conditions to obtain 2-methoxybenzonitrile. 2-methoxybenzonitrile is then oxidized to 2-oxobenzonitrile with copper trichloride in the presence of sodium hydroxide or sodium carbonate. Finally, treatment with hydrogen chloride gives the final product.
Regarding safety information, observe general laboratory safety practices when using and storing. It is a compound that may be irritating to the eyes, skin and respiratory tract, so it is necessary to wear appropriate personal protective equipment, such as laboratory gloves, laboratory glasses and protective face masks. Avoid inhalation and contact with skin during use. If ingested or into the eyes, should immediately rinse with plenty of water, and seek the help of medical personnel.
It is mainly used in the field of organic synthesis and medicine. It can be used as a pharmaceutical intermediate for the synthesis of other compounds, such as antibiotics, anti-tumor drugs, fungicides, etc. In addition, it can also be applied to pesticides, dyes and other fields.
The preparation can be obtained by the reaction of phenol and cuprous chloride. First, phenol is methylated with a methylenating agent under alkaline conditions to obtain 2-methoxybenzonitrile. 2-methoxybenzonitrile is then oxidized to 2-oxobenzonitrile with copper trichloride in the presence of sodium hydroxide or sodium carbonate. Finally, treatment with hydrogen chloride gives the final product.
Regarding safety information, observe general laboratory safety practices when using and storing. It is a compound that may be irritating to the eyes, skin and respiratory tract, so it is necessary to wear appropriate personal protective equipment, such as laboratory gloves, laboratory glasses and protective face masks. Avoid inhalation and contact with skin during use. If ingested or into the eyes, should immediately rinse with plenty of water, and seek the help of medical personnel.
Last Update：2024-04-09 21:01:54
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View History
2-Chloro-6-hydroxybenzoni...
(CARBOETHOXYMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
LABOTEST-BB LT00159813
16-Hydroxyhexadecanoic acid lactone
CHLOROTRIS(TRIMETHYLSILYL)SILANE
Lithium quinolin-8-olate
2-Pyrocatechuic acid
Sodium dihydrobis(2-methoxyethoxy)aluminate
二甲基反式,反式-第二菊酸酯
(CARBOETHOXYMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
LABOTEST-BB LT00159813
16-Hydroxyhexadecanoic acid lactone
CHLOROTRIS(TRIMETHYLSILYL)SILANE
Lithium quinolin-8-olate
2-Pyrocatechuic acid
Sodium dihydrobis(2-methoxyethoxy)aluminate
二甲基反式,反式-第二菊酸酯