2-Chloropropene-3-ol
2-CHLORO-2-PROPEN-1-OL
CAS: 5976-47-6
Molecular Formula: C3H5ClO
2-Chloropropene-3-ol - Names and Identifiers
2-Chloropropene-3-ol - Physico-chemical Properties
| Molecular Formula | C3H5ClO |
| Molar Mass | 92.52 |
| Density | 1.162 g/mL at 25 °C (lit.) |
| Boling Point | 133-134 °C (lit.) |
| Flash Point | 130 °F |
| pKa | 11.45±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | n20/D 1.459(lit.) |
| Physical and Chemical Properties | EPA Chemical Information 2-Chloro-2-propen-1-ol (5976-47-6) |
| Use | Introduction 1, 2-chloro-2-propen-1-ol can be prepared by hydrolysis of 2-chloro-2-propen-1-ol, and then propargyl alcohol and its downstream products can be prepared. 2-chloro-2-propen-1-ol is a key pesticide and pharmaceutical intermediate, so it will be of positive significance to improve the yield of 2-chloro-2-propen-1-ol. There have been many related literature reports on the preparation of 2-chloro -2-propylene -1-alcohol from 1,2-chloro -2-propylene, but the yield of this step is mostly 70%-91% in domestic and foreign reports, and the extractant used is mostly ether or ethyl acetate. |
2-Chloropropene-3-ol - Risk and Safety
| Risk Codes | R10 - Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2920 8/PG 2 |
| WGK Germany | 3 |
| RTECS | UD4725000 |
| Hazard Class | 3.2 |
| Packing Group | III |
2-Chloropropene-3-ol - Upstream Downstream Industry
| Downstream Products | GLYCIDYL METHYL ETHER 2,3-Dichloropropene CHLOROPROPANAL |
2-Chloropropene-3-ol - Uses and synthesis methods
Preparation
1. add 2.1mol of sodium carbonate and 1300ml of water to a 2000ml reaction bottle, then add 3.5 mol1, 2-dichloropropene (396g, content 98%), heat and reflux while stirring, and end the reaction when the content of 1, 2-dichloropropene is less than 2% monitored by gas chromatography. After the reaction, let it stand and stratify, separate the upper and lower layers with a separatory funnel to obtain 1178.8g of the upper 2-chloro-2-propen-1-alcohol aqueous solution, and divide the upper 2-chloro-2-propen-1-alcohol aqueous solution into four equal parts, that is, 294.7g per part.
2. the first part is extracted with ethyl acetate and a centrifugal extractor. the extractant parameters are set to 68.58Hz and 0.2V. the extractant flow rate is controlled at 19 ml/min, the 2-chloro -2-propylene -1-alcohol aqueous solution flow rate is 48 ml/min, and four extractors are connected in series to realize continuous extraction.
3. Distillate the reaction liquid after extraction, recover the extractant and separate and purify the product, collect the 53-55 ℃ fraction, and the gas phase detection content is above 99%. The fraction is the recovered extractant, continue to increase the temperature, and collect the 143-145 ℃ fraction. 38.2 g2-chloro-2-propen-1-ol product was obtained by the first rectification of the extractant as ethyl acetate.
category
Toxic substances
toxicity classification
High toxicity
acute toxicity
oral-mouse LDL0: 63 mg/kg; intravenous-mouse LD50: 56 mg/kg
stimulus data
skin-rabbit 500 mg severe
flammability hazard characteristics
Thermal decomposition discharges toxic chloride fumes
storage and transportation features
The warehouse is ventilated and dry at low temperature; stored separately from food ingredients
fire extinguishing agent
Water, carbon dioxide, foam, dry powder
Last Update：2024-04-10 22:29:15
2-Chloropropene-3-ol - Security information
| Hazard Note | Irritant |
Last Update：2024-04-10 22:29:15
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Downstream Products for 2-Chloropropene-3-ol