2-Chloropyridine-N-Oxide
2-Chloropyridine-N-Oxide
CAS: 2402-95-1
Molecular Formula: C5H4ClNO
2-Chloropyridine-N-Oxide - Names and Identifiers
2-Chloropyridine-N-Oxide - Physico-chemical Properties
| Molecular Formula | C5H4ClNO |
| Molar Mass | 129.54 |
| Density | 1,209g/cm |
| Melting Point | 67-70°C |
| Boling Point | 168-170C |
| Flash Point | 145.6°C |
| Water Solubility | Insoluble in water. |
| Vapor Presure | 0.000733mmHg at 25°C |
| BRN | 108585 |
| pKa | -0.76±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1,531-1,533 |
| MDL | MFCD00129036 |
2-Chloropyridine-N-Oxide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | 2811 |
| HS Code | 29333990 |
| Hazard Class | 6.1 |
| Packing Group | II |
2-Chloropyridine-N-Oxide - Reference Information
| Uses | 2-chloropyridine-N-oxide is an important compound in pyridine nitrogen oxides, an important intermediate for pesticides, medicines and daily chemical products, and an important intermediate for the synthesis of skin cleansers, shampoo and pyrithiamine, it is an essential raw material for the synthesis of an important intermediate synthesis of phenylurea plant growth regulators-2-chloro-4-nitropyridine, especially in the anti-dandruff and antipruritic agent Omartin Zinc (ZPT) and water-soluble anti-mildew antiseptic type Anti-dandruff antipruritic agent PC preservatives are widely used in the production. |
| there are many synthesis methods for preparing | 2-chloropyridine-N-oxide, such as hydrogen peroxide oxidation, peroxyacetic acid oxidation, sodium perborate oxidation, etc. In this experiment, tungstic acid and sulfuric acid are used as catalysts and hydrogen peroxide is used as oxidant. The comparative experiments are carried out from the dosage of catalyst and oxidant, reaction temperature and reaction time, and the optimal reaction conditions are obtained from the exploration rules, so as to provide basic data for the synthesis of 2-chloropyridine nitrogen oxide. Add 25 mL2-chloropyridine, 28mL distilled water, 1.1mL 98% concentrated sulfuric acid and 2.2g tungstic acid into a 250mL four-mouth flask equipped with an electric stirrer, a thermometer, a spherical condenser and a constant pressure dropping funnel, start the stirrer, and then measure 30mL hydrogen peroxide into the constant pressure dropping funnel. Adjust the temperature of the water bath. When the temperature of the reaction solution reaches 70 ℃, start dropping hydrogen peroxide, control the temperature at 70~80 ℃, about 12 hours after dropping, then continue stirring at 75~80 ℃ and keep warm for 24 hours, take samples every 3 hours, and take a total of 8 samples. At the end of the reaction, the solution becomes a light yellow transparent solution, drops to room temperature, analyzes the sample by gas chromatography, and calculates the conversion rate of the reaction. Add 2.5gCaO to the small beaker, then add distilled water to prepare Ca(OH)2 emulsion. Use this emulsion to adjust the pH value of the reaction solution to 6-7, stir for 1h at room temperature, and precipitate is generated. The precipitate is CaWO4, filter and wash the precipitate, and dry for later use. To the filtrate to add the amount of 2-chloropyridine and other substances of dilute hydrochloric acid, so that the product into salt, with a water pump vacuum distillation to evaporate the water dry, to obtain nitrogen oxide 2-chloropyridine hydrochloride, a light yellow solid, its melting point of 141~143 degrees C, consistent with the theoretical value, to calculate the yield. |
Last Update：2024-04-10 22:29:15
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