Name | 5-bromo-2-ethoxypyridine |
Synonyms | 5-Bromo-2-ethoxypyri Bromo-2-ethoxypyridine 2-Ethoxy-5-bromopyridine 5-bromo-2-ethoxypyridine 5-BROMO-2-ETHOXYPYRIDINE 5-Bromo-2-ethoxypyridine 2-ETHOXY-5-BROMOPYRIDINE PYRIDINE, 5-BROMO-2-ETHOXY- 2-Ethoxypyridine-5-bromopyridine |
CAS | 55849-30-4 |
InChI | InChI=1/C7H8BrNO/c1-2-10-7-4-3-6(8)5-9-7/h3-5H,2H2,1H3 |
InChIKey | WQXZKMUZWPUZGL-UHFFFAOYSA-N |
Molecular Formula | C7H8BrNO |
Molar Mass | 202.05 |
Density | 1.449±0.06 g/cm3(Predicted) |
Melting Point | 32-36 °C (lit.) |
Boling Point | 107°C/33mmHg(lit.) |
Flash Point | 218°F |
Vapor Presure | 0.207mmHg at 25°C |
Appearance | Solid |
Color | Off-white to pale yellow |
pKa | 1.68±0.22(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.534 |
MDL | MFCD00234311 |
Physical and Chemical Properties | Melting point 32-36°C flash point 218 °F |
Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - |
WGK Germany | 3 |
HS Code | 29333990 |
Hazard Note | Harmful |
Hazard Class | IRRITANT |
application | 5-bromo-2-ethoxypyridine is a pyridine compound that can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development processes and chemical production processes. |
preparation | (1) add 47 g2, 5-dibromopyridine, 8g solid sodium hydroxide and 200 ml ethanol into a 500 ml reaction bottle, stir and start to raise the temperature to reflux state, the reaction time is 5 hours, the reaction is stopped, most methanol is distilled, and cooled, add 100 ml of water, extract once with dichloromethane, remove dichloromethane to obtain crude product, and distill the crude product under reduced pressure to obtain 5-bromo-2-ethoxypyridine with a yield of 98%. |