2-FLUORO-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE - Names and Identifiers
Name | 2-Fluoropyridine-3-boronic acid pinacol ester
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Synonyms | 2-Fluoro-3-pyridylboronic acid pinacol ester 2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER 2-Fluoropyridine-3-boronic acid pinacol ester pyridine, 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborol 2-FLUORO-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine pyridine, 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
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CAS | 452972-14-4
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InChI | InChI=1/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-6-5-7-14-9(8)13/h5-7H,1-4H3 |
2-FLUORO-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE - Physico-chemical Properties
Molecular Formula | C11H15BFNO2
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Molar Mass | 223.05 |
Density | 1.09±0.1 g/cm3(Predicted) |
Melting Point | 42-45°C |
Boling Point | 309.9±27.0 °C(Predicted) |
Flash Point | 141.2°C |
Vapor Presure | 0.00113mmHg at 25°C |
Appearance | solid |
Color | yellow |
pKa | -0.44±0.12(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.477 |
MDL | MFCD06798245 |
2-FLUORO-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE - Risk and Safety
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37 - Wear suitable gloves.
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TSCA | No |
HS Code | 29319090 |
Hazard Class | IRRITANT |
2-FLUORO-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE - Introduction
2-Fluoropyridine-3-boronic acid pinacol ester, also known as 2-Fluoropyridine-3-boronic acid pinacol ester, is an organic compound. Its chemical formula is C12H16BFNO2 and its molecular weight is 245.07.
The following are the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to light yellow liquid
-Melting point:-20 ℃
-boiling point: 204~205 ℃
-Solubility: Soluble in organic solvents such as ethanol and dimethylformamide
Use:
- 2-Fluoropyridine-3-boronic acid pinacol ester is an important intermediate commonly used in organic synthesis and is widely used in the field of chemical synthesis.
-It can be used to synthesize various heterocyclic compounds and nitrogen-containing compounds, such as drugs, pesticides and photoelectric materials.
Preparation Method:
- 2-Fluoropyridine-3-boronic acid pinacol ester can be prepared in many ways. one common method is to react 2-fluoropyridine fluoride and triphenylberyllium with acidic boric acid ester in an organic solvent, then to obtain the target product through distillation and crystallization purification.
Safety Information:
-The compound is irritating and sensitizing to the skin, and appropriate protective measures should be taken when in contact.
-When handling or using, avoid inhaling its vapor or dust, and pay attention to avoid contact with eyes and skin.
-In case of aspiration or ingestion, seek medical attention immediately.
Last Update:2024-04-09 02:00:46