2-FLUORO-3-(TRIFLUOROMETHYL)ANILINE
2-Fluoro-3-(trifluoromethyl)aniline
CAS: 123973-25-1
Molecular Formula: C7H5F4N
2-FLUORO-3-(TRIFLUOROMETHYL)ANILINE - Names and Identifiers
| Name | 2-Fluoro-3-(trifluoromethyl)aniline |
| Synonyms | BUTTPARK 45 1-71 α,α,α,2-Tetrafluoro-m-toluidine 2-Fluoro-3-aMinobenzotrifluoride 3-AMINO-2-FLUOROBENZOTRIFLUORIDE 2-Fluoro-3-(trifluoromethyl)aniline 2-FLUORO-3-(TRIFLUOROMETHYL)ANILINE [2-Fluoro-3-(trifluoroMethyl)phenyl]aMine ALPHA,ALPHA,ALPHA,2-TETRAFLUORO-M-TOLUIDINE |
| CAS | 123973-25-1 |
| InChI | InChI=1/C7H5F4N/c8-6-4(7(9,10)11)2-1-3-5(6)12/h1-3H,12H2 |
| InChIKey | YKPDYPPZLUZONK-UHFFFAOYSA-N |
2-FLUORO-3-(TRIFLUOROMETHYL)ANILINE - Physico-chemical Properties
| Molecular Formula | C7H5F4N |
| Molar Mass | 179.11 |
| Density | 1.39 g/mL at 25 °C (lit.) |
| Boling Point | 189 °C (lit.) |
| Flash Point | 180°F |
| Solubility | Chloroform (Sparingly), Methanol (Slightly) |
| Vapor Presure | 0.703mmHg at 25°C |
| Appearance | Oil |
| Specific Gravity | 1.390 |
| Color | Colourless |
| pKa | 1.98±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | n20/D 1.462(lit.) |
| Physical and Chemical Properties | WGK Germany:3 |
2-FLUORO-3-(TRIFLUOROMETHYL)ANILINE - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | PG3 |
| WGK Germany | 3 |
| HS Code | 29214300 |
| Hazard Note | Harmful/Irritant |
| Hazard Class | IRRITANT |
2-FLUORO-3-(TRIFLUOROMETHYL)ANILINE - Introduction
2-fluoro-3-trifluoromethylaniline is an organic compound with the chemical formula C7H4F4N. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 2-fluoro-3-trifluoromethylaniline is a colorless to light yellow solid.
-Solubility: It is soluble in organic solvents, such as dimethylformamide (DMF) and dichloromethane, but insoluble in water.
Use:
-Chemical synthesis: 2-fluoro-3-trifluoromethylaniline can be used as an intermediate in organic synthesis to prepare a series of other compounds.
-Pharmaceutical field: It is often used as a raw material in the synthesis of certain drugs, such as anti-cancer drugs and antiviral drugs.
Preparation Method:
The preparation method of 2-fluoro-3-trifluoromethylaniline can be carried out by the following steps:
1.2-amino -4,5-difluorobenzoic acid reacts with trifluoromethylacetamide to generate 2-amino -4,5-difluoro -3-trifluoromethylbenzamide.
2. The intermediate is then reacted with hydrofluoric acid to produce 2-fluoro-3-trifluoromethylaniline.
Safety Information:
-2-fluoro-3-trifluoromethylaniline has strong irritation to eyes and skin and should be avoided.
-It may be harmful to the environment, and care should be taken to prevent it from entering the soil and water sources.
-Follow relevant safety procedures and wear appropriate protective equipment during use or storage.
-In terms of waste disposal, local regulations should be followed and appropriate methods should be used for disposal.
Nature:
-Appearance: 2-fluoro-3-trifluoromethylaniline is a colorless to light yellow solid.
-Solubility: It is soluble in organic solvents, such as dimethylformamide (DMF) and dichloromethane, but insoluble in water.
Use:
-Chemical synthesis: 2-fluoro-3-trifluoromethylaniline can be used as an intermediate in organic synthesis to prepare a series of other compounds.
-Pharmaceutical field: It is often used as a raw material in the synthesis of certain drugs, such as anti-cancer drugs and antiviral drugs.
Preparation Method:
The preparation method of 2-fluoro-3-trifluoromethylaniline can be carried out by the following steps:
1.2-amino -4,5-difluorobenzoic acid reacts with trifluoromethylacetamide to generate 2-amino -4,5-difluoro -3-trifluoromethylbenzamide.
2. The intermediate is then reacted with hydrofluoric acid to produce 2-fluoro-3-trifluoromethylaniline.
Safety Information:
-2-fluoro-3-trifluoromethylaniline has strong irritation to eyes and skin and should be avoided.
-It may be harmful to the environment, and care should be taken to prevent it from entering the soil and water sources.
-Follow relevant safety procedures and wear appropriate protective equipment during use or storage.
-In terms of waste disposal, local regulations should be followed and appropriate methods should be used for disposal.
Last Update：2024-04-09 02:00:41
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Product Name: 2-Fluoro-3-(trifluoromethyl)aniline Request for quotationCAS: 123973-25-1
Tel: +86-18162425036
Email: 3866263148@qq.com
Mobile: 18162425036
QQ: 3866263148
Wechat: 18162425036
Spot supply
Product Name: 2-Fluoro-3-(trifluoromethyl)aniline Request for quotationCAS: 123973-25-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
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