2-FLUORO-4-CHLOROBENZALDEHYDE
4-Chloro-2-fluorobenzaldehyde
CAS: 61072-56-8
Molecular Formula: C7H4ClFO
2-FLUORO-4-CHLOROBENZALDEHYDE - Names and Identifiers
| Name | 4-Chloro-2-fluorobenzaldehyde |
| Synonyms | VHR DG BF 61072-56-8 TIMTEC-BB SBB003985 4-Chloro-2-fluorobenzaldehyde 4-CHLORO-2-FLUOROBENZALDEHYDE 2-FLUORO-4-CHLOROBENZALDEHYDE 2-Fluoro-4-Chlorobenzaldehyde 3-Fluoro-4-formylchlorobenzene 4-Chlor-2-fluorbenzolcarbaldehyd 2-fluoro-4-chlorobenzene Methylal 4-Chloro-2-Fluorobenzaldehyde 2-Fluoro-4-Chlorobenzaldehyde |
| CAS | 61072-56-8 |
| EINECS | 642-855-8 |
| InChI | InChI=1/C7H4ClFO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H |
| InChIKey | UVGYSEIWAOOIJR-UHFFFAOYSA-N |
2-FLUORO-4-CHLOROBENZALDEHYDE - Physico-chemical Properties
| Molecular Formula | C7H4ClFO |
| Molar Mass | 158.56 |
| Density | 1.3310 (estimate) |
| Melting Point | 58-61 °C |
| Boling Point | 118-120 C |
| Flash Point | 80.7°C |
| Water Solubility | Insoluble |
| Vapor Presure | 0.199mmHg at 25°C |
| Appearance | Crystals or Powder |
| Color | White to yellow-beigeor |
| BRN | 3537705 |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | Air Sensitive |
| Refractive Index | 1.559 |
| Physical and Chemical Properties | Off-white crystals |
2-FLUORO-4-CHLOROBENZALDEHYDE - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. |
| TSCA | T |
| HS Code | 29130000 |
| Hazard Note | Irritant |
| Hazard Class | IRRITANT, AIR SENSIT |
2-FLUORO-4-CHLOROBENZALDEHYDE - Reference Information
| Application | 4-chloro-2-fluorophenyl ester is an organic intermediate that can be obtained from 4-chloro-2-fluorobenzoic acid. The raw material is first reduced to obtain (4-chloro-2-fluorophenyl) methanol, and then oxidized to obtain 4-chloro-2-fluorophenyl ester. |
| Preparation | Preparation of (4-chloro-2-fluorophenyl) methanol: At 0°C, to 4-chloro-2-fluorobenzoic acid in THF(15ml) Add LiAlH4 (130mg) to the solution of 300mg-fluorobenzoic acid. The suspension was stirred at 0°C for 16 hours. Dilute the reaction mixture with EA and potassium sodium tartrate aqueous solution and stir at room temperature for 1 hour. Separate the layers and use water to further wash the organic phase. The combined organic layer was dried by MgSO4, filtered and evaporated in vacuum. The crude product was purified by CC(Büchi Sepacore,5g column, solvent A:DCM, solvent B: 3N ammonia in MeOH, ladder degree (expressed in B%):0 to 5, flow rate: 6.0ml/min) to provide 224mg colorless oil. LC-MS(A)tR = 0.68min;[M H]: not seen. Preparation of 4-chloro-2-fluorobenzaldehyde: MnO2(480mg) was added to a solution of (4-chloro-2-fluorophenyl) methanol (222mg) in MeCN(20ml). Stir the mixture for 24 hours. The mixture was filtered by diatomite, the organic layer was dried by MgSO4 and evaporated in vacuum. The crude aldehyde is used in the next step without purification. LC-MS(A):tR = 0.76min;[M H]: not seen. |
| Use | Used as an intermediate in the manufacture of pesticides, medicines and dyes |
Last Update：2024-04-09 20:52:54
