2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE - Names and Identifiers
2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE - Physico-chemical Properties
Molecular Formula | C8H7F4N
|
Molar Mass | 193.14 |
Density | 1.312±0.06 g/cm3(Predicted) |
Boling Point | 173.2±35.0 °C(Predicted) |
pKa | 7.84±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
Sensitive | Air Sensitive |
Refractive Index | 1.4925 |
2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE - Risk and Safety
Hazard Symbols | C - Corrosive
|
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
|
Hazard Note | Corrosive/Store under nitrogen |
Hazard Class | 8 |
2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE - Introduction
2-Fluoro-6-(trifluoromethyl)benzylamine is an organic compound with the chemical formula C8H6F4N and a molecular weight of 205.13. It is a colorless liquid and a volatile solid at room temperature. The following is a detailed description of the nature, use, preparation and safety information of 2-Fluoro-6-(trifluoromethyl) benzene:
Nature:
-Appearance: colorless liquid
-Melting point: -5 ° C
-Boiling point: 146-148 ° c
-Density: 1.351g/cm³
-Refractive Index: 1.477
Use:
2-Fluoro-6-(trifluoromethyl)benzylamine is widely used in organic synthesis, pharmaceutical chemistry and pesticide manufacturing. It is one of the important intermediates in the synthesis of many drugs and pesticides. It can be used as substrate, reagent, solvent and catalyst in organic synthesis.
Method:
2-Fluoro-6-(trifluoromethyl)benzylamine can be synthesized by the following steps:
1. 2-fluoro-6-iodobenzyl alcohol is reacted with trifluoromethyl amine to generate a precursor compound of 2-Fluoro-6-(trifluoromethyl)benzylamine.
2. Alkaline hydrolysis with sodium hydroxide solution to give 2-Fluoro-6-(trifluoromethyl) benzene amine.
Safety Information:
2-Fluoro-6-(trifluoromethyl)benzylamine should be used with caution and follow safe operating methods. During operation and storage, contact with oxidants, strong acids and strong bases should be avoided. Wear appropriate personal protective equipment such as goggles and protective gloves. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. This compound is less toxic and irritating, but it is still recommended to maintain well-ventilated laboratory conditions during operation. To ensure safety, it is recommended to operate and handle this compound under the guidance of suitable institutions or professionals.
Last Update:2024-04-09 15:17:56