2-FLUOROPYRIDIN-3-AMINE
3-(Trifluoromethoxy)benzyl bromide
CAS: 159689-88-0
Molecular Formula: C8H6BrF3O
2-FLUOROPYRIDIN-3-AMINE - Names and Identifiers
2-FLUOROPYRIDIN-3-AMINE - Physico-chemical Properties
| Molecular Formula | C8H6BrF3O |
| Molar Mass | 255.03 |
| Density | 1.572g/mLat 25°C(lit.) |
| Boling Point | 179°C(lit.) |
| Flash Point | 192°F |
| Specific Gravity | 1.5838 |
| BRN | 8052203 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Lachrymatory |
| Refractive Index | n20/D 1.478(lit.) |
2-FLUOROPYRIDIN-3-AMINE - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29093090 |
| Hazard Note | Corrosive/Lachrymatory |
| Hazard Class | 8 |
| Packing Group | III |
2-FLUOROPYRIDIN-3-AMINE - Introduction
3-(Trifluoromethoxy)benzyl bromide is an organic compound with the chemical formula C9H8BrF3O. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless to light yellow liquid.
-Density: 1.624 g/mL.
-Boiling point: 173-175 ° C.
-Melting point:-15 ° C.
-Solubility: Soluble in most organic solvents, such as ethanol, dimethylformamide and a small amount of water.
Use:
- 3-(Trifluoromethoxy)benzyl bromide can be used as an important intermediate in organic synthesis. It can be used to synthesize biologically active compounds, such as anti-tumor drugs, anti-viral drugs, etc.
-It can also be used as a synthesis catalyst and a stabilizer for polymers.
Method:
3-(Trifluoromethoxy)benzyl bromide can be prepared by the following steps:
1. Add trifluoromethanol to the benzyl bromide reactant.
2. A base catalyst such as sodium hydride or Potassium hydride is added to the reaction solution.
3. Stir and heat the reaction mixture at an appropriate temperature.
4. Subsequently, the target product is extracted and purified from the reaction mixture through steps such as extraction and washing.
Safety Information:
- 3-(Trifluoromethoxy)benzyl bromide needs to be careful to prevent contact with skin and eyes during operation and storage.
-Good ventilation and personal protective measures such as gloves, goggles and protective clothing should be taken when handling the compound.
-When using or disposing of the compound, it is necessary to follow local safety practices and regulatory requirements.
-When disposing of the waste of this compound, it should be properly disposed of and comply with relevant regulatory requirements.
Nature:
-Appearance: Colorless to light yellow liquid.
-Density: 1.624 g/mL.
-Boiling point: 173-175 ° C.
-Melting point:-15 ° C.
-Solubility: Soluble in most organic solvents, such as ethanol, dimethylformamide and a small amount of water.
Use:
- 3-(Trifluoromethoxy)benzyl bromide can be used as an important intermediate in organic synthesis. It can be used to synthesize biologically active compounds, such as anti-tumor drugs, anti-viral drugs, etc.
-It can also be used as a synthesis catalyst and a stabilizer for polymers.
Method:
3-(Trifluoromethoxy)benzyl bromide can be prepared by the following steps:
1. Add trifluoromethanol to the benzyl bromide reactant.
2. A base catalyst such as sodium hydride or Potassium hydride is added to the reaction solution.
3. Stir and heat the reaction mixture at an appropriate temperature.
4. Subsequently, the target product is extracted and purified from the reaction mixture through steps such as extraction and washing.
Safety Information:
- 3-(Trifluoromethoxy)benzyl bromide needs to be careful to prevent contact with skin and eyes during operation and storage.
-Good ventilation and personal protective measures such as gloves, goggles and protective clothing should be taken when handling the compound.
-When using or disposing of the compound, it is necessary to follow local safety practices and regulatory requirements.
-When disposing of the waste of this compound, it should be properly disposed of and comply with relevant regulatory requirements.
Last Update：2024-04-09 19:05:47
