2-Fluoro-4-(methylsulfonyl)aniline

2-Fluoro-4-(methylsulfonyl)aniline - Names and Identifiers

Name	2-Fluoro-4-(methylsulfonyl)aniline
Synonyms	2-fluoro-4-Methanesulfonylaniline 2-Fluoro-4-(methylsulfonyl)aniline 4-Amino-3-fluorophenyl methyl sulphone 2-Fluoro-4-(methylsulfonyl)phenylamine 2-fluoro-4-(Methylsulfonyl)benzenaMine Benzenamine, 2-fluoro-4-(methylsulfonyl)- 1-Amino-2-fluoro-4-(methylsulphonyl)benzene
CAS	832755-13-2
InChI	InChI=1/C7H8FNO2S/c1-12(10,11)5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

2-Fluoro-4-(methylsulfonyl)aniline - Physico-chemical Properties

Molecular Formula	C7H8FNO2S
Molar Mass	189.21
Density	1.374±0.06 g/cm3(Predicted)
Melting Point	145-147°C
Boling Point	371.0±42.0 °C(Predicted)
Flash Point	178.168°C
Vapor Presure	0mmHg at 25°C
pKa	-0.04±0.10(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.551

2-Fluoro-4-(methylsulfonyl)aniline - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

2-Fluoro-4-(methylsulfonyl)aniline - Reference Information

Application

2-fluoro-4-(methylsulfonyl) aniline can be used as intermediates in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical production process.

preparation

2-fluoro-4-iodoaniline (206.8g,872.3mmol) in DMSO(1.1L) copper (II) trifluoromethanesulfonate-benzene complex (30.74g,61.1mmol), sodium methanesulfonate (106.9g,1.047mol) and N,N-dimethylethylenediamine (13.2mL,122mmol). The reaction vessel was then placed in an oil
bath preheated to 120 °c and stirred overnight. After cooling to room temperature, the reaction was diluted with water and extracted repeatedly with EtOAc. The combined organic
extracts were rinsed with brine (5x), dried over MgSO4, and the solvent removed. The resulting purple solid was rinsed with diisopropyl ether and then dried in a vacuum oven overnight at room temperature to constant weight to give a dark purple solid, 51.5g, yield 92%

Last Update：2024-04-09 21:01:54