2-Fluoro-4-(trifluoromethyl)pyridine
2-Fluoro-4-trifluoromethyl-pyridine
CAS: 118078-66-3
Molecular Formula: C6H3F4N
2-Fluoro-4-(trifluoromethyl)pyridine - Names and Identifiers
| Name | 2-Fluoro-4-trifluoromethyl-pyridine |
| Synonyms | 2-Fluoro-4-trifluoromethyl-pyridine 2-Fluoro-4-(trifluoromethyl)pyridine pyridine, 2-fluoro-4-(trifluoromethyl)- Pyridine, 2-fluoro-4-(trifluoroMethyl)- alpha,alpha,alpha,2-Tetrafluoro-4-picoline |
| CAS | 118078-66-3 |
| EINECS | 687-071-7 |
| InChI | InChI=1/C6H3F4N/c7-5-3-4(1-2-11-5)6(8,9)10/h1-3H |
2-Fluoro-4-(trifluoromethyl)pyridine - Physico-chemical Properties
| Molecular Formula | C6H3F4N |
| Molar Mass | 165.09 |
| Density | 1.355 g/mL at 25 °C |
| Boling Point | 113℃ |
| Flash Point | 23℃ |
| Water Solubility | Miscible with water, alcohol, acetonitrile and N,N-dimethylformamide |
| Vapor Presure | 5.48mmHg at 25°C |
| pKa | -2.79±0.10(Predicted) |
| Storage Condition | Refrigerated. |
| Refractive Index | n20/D1.400 |
2-Fluoro-4-(trifluoromethyl)pyridine - Risk and Safety
| Risk Codes | R10 - Flammable R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1992 6.1(3) / PGIII |
| WGK Germany | 3 |
| Hazard Class | 3 |
| Packing Group | III |
2-Fluoro-4-(trifluoromethyl)pyridine - Introduction
2-Fluoro-4-trifluoromethylpyridine is an organic compound with a chemical formula of C7H2F4N and a molecular weight of 191.09g/mol.
The properties of the compound are as follows:
-Appearance: colorless liquid
-Melting point:-45°C
-Boiling Point: 97°C
-Density: 1.5g/cm³
-Solubility: with strong solubility, soluble in water, alcohol, ether and other organic solvents.
2-Fluoro-4-trifluoromethylpyridine has many uses in industry:
-As a catalyst: a catalyst that can be used for organic synthesis reactions, such as oxidation reactions, aldehyde synthesis, etc.
-As a solvent: Due to its good solubility, it can be used as a solvent medium in organic synthesis.
-As additives and intermediates: can be used as additives for polymers and coatings, and can also be used for the synthesis of pesticides and pharmaceutical intermediates.
Preparation of 2-fluoro-4-trifluoromethylpyridine:
One method for preparing 2-fluoro-4-trifluoromethylpyridine is to react pyridine with trifluoroacetyl fluoride under basic conditions. Pyridine is first dissolved in anhydrous methanol, then trifluoroacetyl fluoride is added gradually and the pH is adjusted with a base such as sodium hydroxide. After the reaction was carried out, the product was extracted by distillation.
Safety Information for 2-Fluoro-4-Trifluoromethylpyridine:
-The compound is irritating and corrosive. After contact with skin and eyes, rinse immediately with plenty of water and seek medical help.
-When using, pay attention to avoid inhaling the vapor of the compound, and operate in a well-ventilated place.
-Store away from fire and heat sources, and avoid contact with oxidants and acids.
-Personal protective equipment such as protective gloves, goggles and protective clothing should be worn when using or handling the compound to ensure safe handling.
The properties of the compound are as follows:
-Appearance: colorless liquid
-Melting point:-45°C
-Boiling Point: 97°C
-Density: 1.5g/cm³
-Solubility: with strong solubility, soluble in water, alcohol, ether and other organic solvents.
2-Fluoro-4-trifluoromethylpyridine has many uses in industry:
-As a catalyst: a catalyst that can be used for organic synthesis reactions, such as oxidation reactions, aldehyde synthesis, etc.
-As a solvent: Due to its good solubility, it can be used as a solvent medium in organic synthesis.
-As additives and intermediates: can be used as additives for polymers and coatings, and can also be used for the synthesis of pesticides and pharmaceutical intermediates.
Preparation of 2-fluoro-4-trifluoromethylpyridine:
One method for preparing 2-fluoro-4-trifluoromethylpyridine is to react pyridine with trifluoroacetyl fluoride under basic conditions. Pyridine is first dissolved in anhydrous methanol, then trifluoroacetyl fluoride is added gradually and the pH is adjusted with a base such as sodium hydroxide. After the reaction was carried out, the product was extracted by distillation.
Safety Information for 2-Fluoro-4-Trifluoromethylpyridine:
-The compound is irritating and corrosive. After contact with skin and eyes, rinse immediately with plenty of water and seek medical help.
-When using, pay attention to avoid inhaling the vapor of the compound, and operate in a well-ventilated place.
-Store away from fire and heat sources, and avoid contact with oxidants and acids.
-Personal protective equipment such as protective gloves, goggles and protective clothing should be worn when using or handling the compound to ensure safe handling.
Last Update：2024-04-09 21:04:16
