2-HYDROXY-4-FORMYLPYRIDINE

2-HYDROXY-4-FORMYLPYRIDINE - Names and Identifiers

Name	2-HYDROXY-4-PYRIDINECARBOXALDEHYDE
Synonyms	2-HYDROXY-4-FORMYLPYRIDINE 2-Hydroxyisonicotinaldehyde 2-HYDROXY-PYRIDINE-4-CARBALDEHYDE 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE 2-HYDROXYPYRIDINE-4-CARBOXALDEHYDE 2-AMINO-5-(AMINOMETHYL)-4-METHYLTHIAZOLE 2-Oxo-1,2-dihydro-pyridine-4-carbaldehyde 4-Pyridinecarboxaldehyde,1,2-dihydro-2-oxo-(9CI)
CAS	188554-13-4

2-HYDROXY-4-FORMYLPYRIDINE - Physico-chemical Properties

Molecular Formula	C6H5NO2
Molar Mass	123.11
Density	1.365±0.06 g/cm3(Predicted)
Melting Point	79-81 °C
Boling Point	333.7±42.0 °C(Predicted)
pKa	11.17±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

2-HYDROXY-4-FORMYLPYRIDINE - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes R43 - May cause sensitization by skin contact
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.

2-HYDROXY-4-FORMYLPYRIDINE - Reference Information

Use

2-hydroxy-4-pyridinal is an organic intermediate, it can be obtained from 2-hydroxy-4-methylpyridine by oxidation of selenium dioxide. 2-hydroxy-4-pyridinaldehyde can be used to prepare a Ror-γ modulator.

preparation

add anhydrous dioxane (35 mL) to 2-hydroxy-4-methylpyridine (2.10g,19.2 mmol) and selenium dioxide (2.50g,22.5 mmol). The heterogeneous solution was refluxed under argon for 48 hours. The mixture was cooled to room temperature.

The mixture was treated with sodium bicarbonate (1.5g). The mixture was stirred for 3 hours to neutralize the acidic by-products. The resulting dark brown suspension was filtered through a pad of magnesium sulfate (2.5g), florisi (2.5g) and celite (2.5g) to remove insoluble residues. The yellow filtrate was concentrated in vacuo to give the crude compound (1.40g). The crude product was purified by silica gel column chromatography in ethyl acetate and 9:1 ethyl acetate/methanol to obtain 2-hydroxy-4-pyridinaldehyde.

Last Update：2024-04-09 20:52:54