2-HYDROXYCINNAMALDEHYDE

2-HYDROXYCINNAMALDEHYDE - Names and Identifiers

Name	3-(2-Hydroxyphenyl)-2-Propenal
Synonyms	AKOS BC-1812 Hydroxycinnamaldehyde o-hydroxy-cinnamaldehyd o-hydroxycinnamaldehyde 2-HYDROXYCINNAMALDEHYDE 2-hydroxycinnamicaldehyde 3-(2-hydroxyphenyl)-2-propena 3-(2-HYDROXYPHENYL)-2-PROPENAL 3-(2-Hydroxyphenyl)-2-Propenal
CAS	3541-42-2
EINECS	204-683-8

2-HYDROXYCINNAMALDEHYDE - Physico-chemical Properties

Molecular Formula	C9H8O2
Molar Mass	148.16
Density	1.174±0.06 g/cm3(Predicted)
Melting Point	126 °C
Boling Point	311.3±17.0 °C(Predicted)
Solubility	Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
Appearance	Solid
Color	Yellow to Dark Yellow
pKa	8.99±0.35(Predicted)
Storage Condition	-20°C Freezer, Under inert atmosphere

2-HYDROXYCINNAMALDEHYDE - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes R43 - May cause sensitization by skin contact
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
RTECS	GD6565000

2-HYDROXYCINNAMALDEHYDE - Reference

Reference

1. Zhang Yong, Ding Yue, Zhang Tong, Wang Bing, Wang Xinhong, Wu Weigang. Evaluation of Cinnamomum cassia with different growth years by HPLC fingerprint combined with Chemometrics [J]. Chinese traditional medicines, 2021,43(02):543-546.

2-HYDROXYCINNAMALDEHYDE - Reference Information

Application

2-hydroxycinnamaldehyde can be used as an intermediate in organic synthesis and chemical and pharmaceutical synthesis, mainly used in laboratory research and development process and chemical and pharmaceutical synthesis process.

preparation

to 2-hydroxybenzaldehyde (10g,81.8mmol) in THF(150ml) at room temperature to the solution was added (formylmethylene) triphenylphosphine (24.89g,81.8mmol). The resulting reaction mixture was refluxed at 100 °c for 20 hours. The reaction mixture was cooled to room temperature and extracted with water (200ml) and ethyl acetate (3 x 150ml). The combined organic phases were washed with water (150ml), brine (150ml), dried over sodium sulfate and concentrated in vacuo to give the desired crude product. The crude product was purified by column chromatography using normal phase silica gel. The desired product was eluted in about 20-30% ethyl acetate in hexane. The product fractions were evaporated to give 8.7g (yield, 71.86%) of the desired compound as a yellow solid.

Last Update：2024-04-09 19:05:15