2-Hydroxy-4-fluoroanisole
5-Fluoro-2-methoxyphenol
CAS: 72955-97-6
Molecular Formula: C7H7FO2
2-Hydroxy-4-fluoroanisole - Names and Identifiers
2-Hydroxy-4-fluoroanisole - Physico-chemical Properties
| Molecular Formula | C7H7FO2 |
| Molar Mass | 142.13 |
| Density | 1.224 |
| Boling Point | 223°C |
| Flash Point | 111°C |
| Vapor Presure | 0.0645mmHg at 25°C |
| pKa | 8.97±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.511 |
2-Hydroxy-4-fluoroanisole - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Note | Irritant |
2-Hydroxy-4-fluoroanisole - Reference Information
| Application | 5-fluoro-2-methoxyphenol is an important pesticide and pharmaceutical intermediate, methyl ether as raw materials in butyl lithium, trimethoxy boron synthesis for the treatment of high blood pressure drug alicron. |
| preparation | in a 500 mL Four-necked flask, add 150 g (0.9 mol) of acetyl guaiacol, 240 of glacial acetic acid, iodine 2.5g(0.01 mol) at 25 ℃, under stirring liquid bromine 160g(2 mol), Dropwise added, heated to 100 ℃ for 10 h, the reaction mixture was cooled to room temperature, extracted twice with 3000 mL of ethyl acetate, and the ethyl acetate layers were combined. The mixture was washed with 500 mL of saturated sodium sulfite and then with 500 mL of saturated brine, and the ethyl acetate was recovered to obtain a crude product, light yellow gum 180.0g, purity 98.3%, yield 80.2%. |
Last Update：2024-04-10 22:30:50
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Product Name: 5-Fluoro-2-methoxyphenol Visit Supplier Webpage Request for quotation
CAS: 72955-97-6
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CAS: 72955-97-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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