| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| properties | 2-iodanisole is a light yellow liquid with a melting point of 8-10°C and a boiling point of 125-126°C (96.8kPa), soluble in organic solvents such as alcohol and ether, insoluble in water, and easy to decompose and precipitate iodine when light is seen. |
| application | 2-iodoanisole is an important general chemical reagent, a key synthetic intermediate in pharmacy, liquid crystal, scientific research and other aspects, and has a wide range of applications in the field of organic synthesis. |
| preparation | (1) prepare 2 moles of 20% NaI aqueous solution a and 2.1 moles of 8 ~ 10% sodium hypochlorite aqueous solution B for standby;(2) add 900g anisole to a 2L four-mouth round bottom flask equipped with stirring, temperature display and two constant pressure drop funnels, and heat to 60~70 ℃ under stirring. Then, under stirring, according to the molar ratio of 1:1.05, add sodium iodide solution and sodium hypochlorite solution dropwise at the same time;(3) After the dropwise addition, raise the temperature to 75~80 ℃, stir for 1 hour to obtain a light yellow reaction solution; cool to room temperature and stand The phase is divided; the organic phase is washed with water, dried and filtered to obtain an anisole solution of 2-iodoanisole, which is rectified, cooled, and solidified to obtain white lumpy crystals, that is, 2-iodoanisole, its content is ≥ 98.5%, and the yield is 93.4%. |
