2-Iodopyridin-3-amine
2-Iodopyridin-3-ylamine
CAS: 209286-97-5
Molecular Formula: C5H5IN2
2-Iodopyridin-3-amine - Names and Identifiers
| Name | 2-Iodopyridin-3-ylamine |
| Synonyms | 2-Iodo-3-pyridinamine 2-Iodopyridin-3-amine 2-iodopyridin-3-aMine 2-Iodo-3-aMinopyridine 3-Pyridinamine, 2-iodo- 3-pyridinamine, 2-iodo- 2-Iodopyridin-3-ylamine 2-Lodo-pyridin-3-ylaMine 2-IODO-PYRIDIN-3-YLAMINE 2-Iodo-pyridin-3-ylamine 2-iodine-3-aminopyridine |
| CAS | 209286-97-5 |
| EINECS | 818-662-1 |
| InChI | InChI=1/C5H5IN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2 |
2-Iodopyridin-3-amine - Physico-chemical Properties
| Molecular Formula | C5H5IN2 |
| Molar Mass | 220.01 |
| Density | 2.055±0.06 g/cm3(Predicted) |
| Boling Point | 327.2±27.0 °C(Predicted) |
| Flash Point | 151.7°C |
| Vapor Presure | 0.000205mmHg at 25°C |
| Appearance | White-like powder |
| pKa | 2.78±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.702 |
2-Iodopyridin-3-amine - Introduction
2-Iodopyridin-3-ylamine is an organic compound with the chemical formula C5H5IN2. The following is a description of some properties, uses, preparation and safety information about 2-iodopyridin-3-amine:
Nature:
-Appearance: 2-Iodopyridin-3-ylamine is a colorless crystal or white solid.
-Solubility: Soluble in a variety of organic solvents, such as chloroform, ethanol and dimethyl sulfite, insoluble in water.
-Melting point: About 100-102 ℃.
-Stability: 2-Iodopyridin-3-ylamine may decompose under light and is sensitive to air. Protective measures should be taken when encountering light and air.
Use:
-Medicinal chemistry: 2-iodyridin-3-ylamine is commonly used as a drug intermediate for the synthesis of antibiotics, anticancer drugs, etc.
-Organic synthesis: In organic synthetic chemistry, 2-Iodopyridin-3-ylamine can be used as an alkaline reagent to catalyze the hydroxyamidation of ketones.
Method:
The preparation of 2-Iodopyridin-3-ylamine is generally carried out by the following steps:
-Step 1: First, pyridine is dissolved in dilute sulfuric acid.
-Step 2: Then, under low temperature conditions, iodine is added to the solution of step 1, and the reaction generates 2-iodo-pyridine.
-Step 3: Finally, the generated 2-iodo-pyridine is reacted with aqueous ammonia to obtain the final product 2-Iodopyridin-3-ylamine.
Security Information:
- 2-Iodopyridin-3-ylamine is an organic compound, you need to pay attention to personal protective equipment when handling, such as wearing gloves, goggles, etc.
-Since 2-Iodopyridin-3-ylamine is sensitive to air and light, it should be stored in a light-proof, sealed container and kept dry.
-Avoid contact with skin, eyes and mucous membranes during use or handling. If you touch them carelessly, wash them with plenty of water immediately and seek medical attention in time.
-In the laboratory and industrial environment, the relevant safety procedures and operating instructions need to be observed.
Nature:
-Appearance: 2-Iodopyridin-3-ylamine is a colorless crystal or white solid.
-Solubility: Soluble in a variety of organic solvents, such as chloroform, ethanol and dimethyl sulfite, insoluble in water.
-Melting point: About 100-102 ℃.
-Stability: 2-Iodopyridin-3-ylamine may decompose under light and is sensitive to air. Protective measures should be taken when encountering light and air.
Use:
-Medicinal chemistry: 2-iodyridin-3-ylamine is commonly used as a drug intermediate for the synthesis of antibiotics, anticancer drugs, etc.
-Organic synthesis: In organic synthetic chemistry, 2-Iodopyridin-3-ylamine can be used as an alkaline reagent to catalyze the hydroxyamidation of ketones.
Method:
The preparation of 2-Iodopyridin-3-ylamine is generally carried out by the following steps:
-Step 1: First, pyridine is dissolved in dilute sulfuric acid.
-Step 2: Then, under low temperature conditions, iodine is added to the solution of step 1, and the reaction generates 2-iodo-pyridine.
-Step 3: Finally, the generated 2-iodo-pyridine is reacted with aqueous ammonia to obtain the final product 2-Iodopyridin-3-ylamine.
Security Information:
- 2-Iodopyridin-3-ylamine is an organic compound, you need to pay attention to personal protective equipment when handling, such as wearing gloves, goggles, etc.
-Since 2-Iodopyridin-3-ylamine is sensitive to air and light, it should be stored in a light-proof, sealed container and kept dry.
-Avoid contact with skin, eyes and mucous membranes during use or handling. If you touch them carelessly, wash them with plenty of water immediately and seek medical attention in time.
-In the laboratory and industrial environment, the relevant safety procedures and operating instructions need to be observed.
Last Update：2024-04-09 21:04:16
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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