2-METHYL-3-BROMOPYRIDINE
2-methyl-3-bromo pyridine
CAS: 38749-79-0
Molecular Formula: C6H6BrN
2-METHYL-3-BROMOPYRIDINE - Names and Identifiers
| Name | 2-methyl-3-bromo pyridine |
| Synonyms | 3-Bromo-2-picoline 3-BROMO-2-PICOLINE 3-bromo-2-methylpridine 2-METHYL-3-BROMOPYRIDINE 3-BROMO-2-METHYLPYRIDINE 2-methyl-3-bromopyridine 3-bromo-2-methylpyridine 2-methyl-3-bromo pyridine Pyridine, 3-bromo-2-methyl- 3-BROMO-2-METHYLPYRIDINE (3-BROMO-2-PICOLINE) |
| CAS | 38749-79-0 |
| EINECS | 625-249-8 |
| InChI | InChI=1/C6H6BrN/c1-5-6(7)3-2-4-8-5/h2-4H,1H3 |
| InChIKey | AIPWPTPHMIYYOX-UHFFFAOYSA-N |
2-METHYL-3-BROMOPYRIDINE - Physico-chemical Properties
| Molecular Formula | C6H6BrN |
| Molar Mass | 172.02 |
| Density | 1.495 |
| Boling Point | 76°C/17mm |
| Flash Point | 174°F |
| Vapor Presure | 1.27mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear, colorless to brown |
| pKa | 3.59±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.5604 |
| MDL | MFCD00191224 |
| Physical and Chemical Properties | Density: 1.549 |
| Use | The NBS-dibromination reaction initiated by peroxide and the subsequent hydrolysis reaction can be converted into the corresponding pyridine formaldehyde. |
2-METHYL-3-BROMOPYRIDINE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
2-METHYL-3-BROMOPYRIDINE - Reference Information
| use | 2-methyl -3-bromopyridine is an important intermediate, mainly used as pharmaceutical intermediate, organic synthesis intermediate, organic solvent, and also used in the production of dyes, fragrances and pesticides. The NBS-based dibromination reaction initiated by peroxide and the subsequent hydrolysis reaction are converted into the corresponding pyridine formaldehyde. |
| synthesis method | (1) diethyl malonate reacts with alkali metals to form a salt, and then drops the toluene solution of 2-chloro -3-nitropyridine for condensation reaction, and then decarboxylation under acidic conditions to obtain 2-methyl -3-nitropyridine; (2) 2-methyl -3-nitropyridine under Pd/C catalysis, methanol is used as solvent, hydrogenation reduction, suction filtration, filtrate concentration to obtain 2-methyl -3-aminopyridine; (3) 2-methyl -3-aminopyridine first forms salt with acid, cools to-KTC-O °C, drops bromine, drops sodium nitrite aqueous solution, drops after dropping, adjusts the pH of the solution to be alkaline, and then extracts, dries, and concentrates to obtain 2-methyl -3-bromopyridine. |
Last Update：2024-04-09 19:05:12
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