2-METHYL-BETA-CARBOLINE
Harmane
CAS: 486-84-0
Molecular Formula: C12H10N2
2-METHYL-BETA-CARBOLINE - Names and Identifiers
2-METHYL-BETA-CARBOLINE - Physico-chemical Properties
| Molecular Formula | C12H10N2 |
| Molar Mass | 182.22 |
| Density | 1.1485 (rough estimate) |
| Melting Point | 235-238°C(lit.) |
| Boling Point | 305.62°C (rough estimate) |
| Water Solubility | 1523g/L(20 ºC) |
| Solubility | Almost insoluble (0.04g/L) (25°C), |
| Appearance | Powder |
| Color | White to Dark Brown |
| Merck | 13,4630 |
| BRN | 143898 |
| pKa | 7.37, 14.6(at 25℃) |
| Storage Condition | Store at RT |
| Sensitive | Avoid contact with oxides |
| Refractive Index | 1.6266 (estimate) |
| MDL | MFCD00004957 |
2-METHYL-BETA-CARBOLINE - Risk and Safety
| Risk Codes | R20/21 - Harmful by inhalation and in contact with skin. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | UV0280000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 i.p. in mice: 50 mg/kg (Sigg) |
2-METHYL-BETA-CARBOLINE - Reference
| Reference Show more | 1. Xin, Dong, Dong, Lu, Keyang, Wang, Shan, et al. Response surface methodology for extracting egg butter by ethanol extraction [J]. Food Science and Technology 2019 v.44;No.336(10):267-274. 2. Zhao Tianpei, Ma Yuxiang, Zhang chenxia, Xi Jun, Wang Xuede. Study on the properties of reaction products of β-carboline heterocyclic amine model system [J]. Journal of Henan University of Technology (Natural Science Edition),2021,42(01):27-34 62. |
2-METHYL-BETA-CARBOLINE - Reference Information
| Application | halmanine is mainly used for fungal dermatosis, eczema, burns, varicose ulcer and other symptoms (interphalangeal Trichophyton, MIC = 1.6~200.0 μg/mL); Low dose is movement inhibitor, high dose causes convulsion; Inhibition of active sodium transfer, Na +,K +-ATPase inhibitors; Plant growth regulators; Uterine stimulants. Halman is used clinically to treat diseases caused by low levels of epinephrine or norepinephrine. Blood stasis, cure Cough, fatigue hematemesis, bruises, irregular menstruation. |
| biological activity | Harman, a β-carboline alkaloid (BCA), is a potent neurotoxin, can cause severe movement tremor and psychiatric manifestations. Harman E was 1000-fold more selective for the I1 imidazoline receptor (I1-Imidazoline receptor, IC50 = 30 nM) than for the α2-adrenoceptor (IC50=18 μm). Harmane is also A potent and selective monoamine oxidase inhibitor (IC50 values of 0.5 μm and 5 μm for MAO A/B, respectively). Harmane has a mutagenic effect. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | intraperitoneal-mouse LD50: 50 mg/kg; Subcutaneous-rabbit LD50: 200 mg/kg |
| flammability hazard characteristics | flammability; Toxic NOx smoke from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-09 15:16:54
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Product Name: Harmane Visit Supplier Webpage Request for quotationCAS: 486-84-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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