2-METHYL-PYRIMIDINE-4,6-DIOL
4,6-Dihydroxy-2-methylpyrimidine
CAS: 40497-30-1
Molecular Formula: C5H6N2O2
2-METHYL-PYRIMIDINE-4,6-DIOL - Names and Identifiers
| Name | 4,6-Dihydroxy-2-methylpyrimidine |
| Synonyms | 2-METHYL-4,6-PYRIMIDINEDIOL 2-METHYL-PYRIMIDINE-4,6-DIOL 2-Methyl-4,6-pyrimidinedione 4,6-Dihydroxy-2-methylpyrimidine 4,6-DIHYDROXY-2-METHYLPYRIMIDINE 4,6-dihydroxyl-2-methylpyrimidine 2-METHYL-4,6-DIHYDROXY PYRIMIDINE 2-methyl-1H,5H-pyrimidine-4,5-dione 4,6(1H,5H)-Pyrimidinedione, 2-methyl- (9CI) |
| CAS | 40497-30-1 |
| EINECS | 254-941-9 |
| InChI | InChI=1/C5H6N2O2/c1-3-6-4(8)2-5(9)7-3/h2H2,1H3,(H,6,7,8,9) |
2-METHYL-PYRIMIDINE-4,6-DIOL - Physico-chemical Properties
| Molecular Formula | C5H6N2O2 |
| Molar Mass | 126.11 |
| Density | 1.44g/cm3 |
| Melting Point | 360℃ |
| Boling Point | 234.21°C (rough estimate) |
| Appearance | White to bright light brown powder |
| Storage Condition | Room Temprature |
| Refractive Index | 1.619 |
| MDL | MFCD00006104 |
| Physical and Chemical Properties | Melting Point: 360°C |
| Use | For the synthesis of pharmaceutical intermediates |
2-METHYL-PYRIMIDINE-4,6-DIOL - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 1759 |
2-METHYL-PYRIMIDINE-4,6-DIOL - Upstream Downstream Industry
2-METHYL-PYRIMIDINE-4,6-DIOL - Nature
| storage conditions | Sealed in dry,Room Temperature |
| solubility | Soluble in sodium hydroxide. |
| acidity coefficient (pKa) | 9.42±0.20(Predicted) |
| BRN | 115646 |
Last Update：2024-04-10 22:29:15
2-METHYL-PYRIMIDINE-4,6-DIOL - Uses and synthesis methods
application
4, 6-dihydroxy-2-methylpyrimidine can be used as an intermediate in organic synthesis. The compound is used to produce explosives -1, 1-diamino-2, 2-dinitroethylene (DADNE,FOX7), and its application in the synthesis of biologically active substances can also be found.
Preparation
4, 6-dihydroxy-2-methylpyrimidine is prepared as follows: in a reaction flask equipped with a mechanical stirrer, reflux condenser, thermometer and dropping funnel, put 200ml of isopropanol, pour 27g(0.5mol) of sodium methoxide, and heat at 40-50°C until completely dissolved, then add 20ml (0.125 mol) of malonate, mix for 10-15 minutes, then 22 grams (0.373 moles) of acetamide were added in batches under vigorous stirring. The reaction material is quickly heated to boiling and boiled for 4 hours, then the solvent is distilled, and 100ml of water is added to the residue at a temperature of 50-60°C, and the precipitate is completely dissolved. The resulting salt solution was acidified with glacial acetic acid at 50 ÷ 60°C to a pH of 5-6, slowly cooled and settled at a temperature of 18-25°C for 10 hours. Filter out the precipitated product and wash with water (3 × 30ml) and alcohol (2 × 20ml). 9.9g (62.9% of the theoretical value) of 4, 6-dihydroxy-2-methylpyrimidine with a basic substance content of 95% was obtained.
Last Update：2024-04-10 22:29:15
2-METHYL-PYRIMIDINE-4,6-DIOL - Security information
| WGK Germany | 3 |
| HazardClass | 8 |
| PackingGroup | II |
| customs code | 29335995 |
Last Update：2024-04-10 22:29:15
Supplier List
Product Name: 4,6-Dihydroxy-2-methylpyrimidine Request for quotation
CAS: 40497-30-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 40497-30-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: 2-Methylpyrimidine-4,6(1H,5H)-dione Visit Supplier Webpage Request for quotation
CAS: 40497-30-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 40497-30-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 4,6-Dihydroxy-2-methylpyrimidine Request for quotation
CAS: 40497-30-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 40497-30-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: 2-Methylpyrimidine-4,6(1H,5H)-dione Visit Supplier Webpage Request for quotation
CAS: 40497-30-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 40497-30-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for 2-METHYL-PYRIMIDINE-4,6-DIOL
Downstream Products for 2-METHYL-PYRIMIDINE-4,6-DIOL
5-Amino-4,6-dichloro-2-methylpyrimidine
4,6-Dichloro-2-methyl-5-nitropyrimidine
2-METHYL-5-NITRO-PYRIMIDINE-4,6-DIOL
4-Pyrimidinamine, 2-methyl- (9CI)
4-Amino-6-chloro-2-methylpyrimidine
4,6-Dichloro-2-methyl-5-nitropyrimidine
2-METHYL-5-NITRO-PYRIMIDINE-4,6-DIOL
4-Pyrimidinamine, 2-methyl- (9CI)
4-Amino-6-chloro-2-methylpyrimidine