2-Methylpyrimidine
2-Methylpyrimidine
CAS: 5053-43-0
Molecular Formula: C5H6N2
2-Methylpyrimidine - Names and Identifiers
| Name | 2-Methylpyrimidine |
| Synonyms | 2-METHYLPYRIMIDINE 2-Methylpyrimidine Pyrimidine, 2-methyl- 2-methylpyrimidine analogue 2-Methylpyrimidin2-Methylpyrimidinee Pyrimidine, 2-methyl- (6CI,7CI,8CI,9CI) 2-methylpyrimidine(2-methyl-pyrimidine) |
| CAS | 5053-43-0 |
| EINECS | 624-174-8 |
| InChI | InChI=1/C5H6N2/c1-5-6-3-2-4-7-5/h2-4H,1H3 |
| InChIKey | LNJMHEJAYSYZKK-UHFFFAOYSA-N |
2-Methylpyrimidine - Physico-chemical Properties
| Molecular Formula | C5H6N2 |
| Molar Mass | 94.11 |
| Density | 1.0132 g/mL at 25 °C |
| Melting Point | -4°C |
| Boling Point | 165.6°C (rough estimate) |
| Flash Point | 38°C |
| Vapor Presure | 17mmHg at 25°C |
| Specific Gravity | 1.02 |
| pKa | 1.85±0.13(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | n20/D 1.4930 |
| MDL | MFCD00128182 |
2-Methylpyrimidine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. |
| UN IDs | 1993 |
| WGK Germany | 3 |
2-Methylpyrimidine - Introduction
2-Methylpyrimidine is an organic compound with the chemical formula C5H6N2, which is a liquid substance that is a colorless liquid. The following is a brief description of the nature, use, preparation and safety information of 2-Methylpyrimidine:
Nature:
1. appearance and state: colorless liquid.
2. solubility: soluble in many organic solvents, such as alcohols, ethers and drunk.
3. melting point:-12.6 ℃
4. Boiling point: 118-119 ℃
5. Density: about 1.011 g/mL
Use:
1. 2-Methylpyrimidine can be used as an intermediate for the synthesis of other organic compounds, such as pesticides, dyes and drugs.
2. It can also be used as a solvent and catalyst.
Preparation Method:
There are several preparation methods of 2-Methylpyrimidine, the most common method is to start from dimethyl adipate through the esterification reaction of cyanoacetate and the degradation reaction of Tufts = Cohen. Specific steps are as follows:
1. First, dimethyl adipate is reacted with cyanoacetate to generate 2-methyl -4, 5-dicarbonylpyrimidine, the precursor of 2-Methylpyrimidine.
2. Next, the precursor is reacted with iron powder and boric acid to obtain 2-Methylpyrimidine.
Safety Information:
1. 2-Methylpyrimidine should pay attention to fire and explosion prevention during use and storage.
2. contact with skin and eyes may cause irritation, should avoid direct contact.
3. inhalation or ingestion may cause poisoning, should ensure that the use of a well-ventilated area.
4. use should wear appropriate personal protective equipment, such as gloves and protective glasses.
5. in the use and storage, should follow the relevant chemical safety procedures and measures.
Please note that for specific work related to the preparation and use of 2-Methylpyrimidine, please refer to the relevant scientific literature and laboratory operating instructions, and ensure that the correct laboratory safety operating procedures are followed.
Nature:
1. appearance and state: colorless liquid.
2. solubility: soluble in many organic solvents, such as alcohols, ethers and drunk.
3. melting point:-12.6 ℃
4. Boiling point: 118-119 ℃
5. Density: about 1.011 g/mL
Use:
1. 2-Methylpyrimidine can be used as an intermediate for the synthesis of other organic compounds, such as pesticides, dyes and drugs.
2. It can also be used as a solvent and catalyst.
Preparation Method:
There are several preparation methods of 2-Methylpyrimidine, the most common method is to start from dimethyl adipate through the esterification reaction of cyanoacetate and the degradation reaction of Tufts = Cohen. Specific steps are as follows:
1. First, dimethyl adipate is reacted with cyanoacetate to generate 2-methyl -4, 5-dicarbonylpyrimidine, the precursor of 2-Methylpyrimidine.
2. Next, the precursor is reacted with iron powder and boric acid to obtain 2-Methylpyrimidine.
Safety Information:
1. 2-Methylpyrimidine should pay attention to fire and explosion prevention during use and storage.
2. contact with skin and eyes may cause irritation, should avoid direct contact.
3. inhalation or ingestion may cause poisoning, should ensure that the use of a well-ventilated area.
4. use should wear appropriate personal protective equipment, such as gloves and protective glasses.
5. in the use and storage, should follow the relevant chemical safety procedures and measures.
Please note that for specific work related to the preparation and use of 2-Methylpyrimidine, please refer to the relevant scientific literature and laboratory operating instructions, and ensure that the correct laboratory safety operating procedures are followed.
Last Update：2024-04-09 21:01:54
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