2-PHENOXYLETHYLAMINE

2-PHENOXYLETHYLAMINE - Names and Identifiers

Name	2-Phenoxyethylamine
Synonyms	BUTTPARK 9757-78 2-phenoxyethylamino 2-PHENOXYETHYLAMINE 2-Phenoxyethylamine 2-Phenoxyethanamine 2-PHENOXYLETHYLAMINE 2-phenoxyethylammonium alpha-phenoxy-beta-aminoethane
CAS	1758-46-9
EINECS	217-153-6
InChI	InChI=1/C8H11NO/c9-6-7-10-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1

2-PHENOXYLETHYLAMINE - Physico-chemical Properties

Molecular Formula	C8H11NO
Molar Mass	137.18
Density	1.048 g/mL at 25 °C (lit.)
Boling Point	101-103 °C/4 mmHg (lit.)
Flash Point	225°F
Vapor Presure	0.0665mmHg at 25°C
Specific Gravity	1.048
BRN	774671
pKa	8.18±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Sensitive	Air Sensitive
Refractive Index	n20/D 1.536(lit.)
Use	For the synthesis of Nefazodone and other raw materials

2-PHENOXYLETHYLAMINE - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2735 8/PG 3
WGK Germany	3
RTECS	KR9500000
HS Code	29221990
Hazard Class	8
Packing Group	III

2-PHENOXYLETHYLAMINE - Reference Information

use

2-phenoxyethylamine is an important intermediate in the production of nefazodone. Nefazodone, an antidepressant for benpiperazine. The structure is related to trazodone. It can block the reuptake of 5-HT by presynaptic neurons and is an antagonist of postsynaptic 5-HT2 receptors. Unlike trazodone, 2-phenoxyethylamine inhibits the reuptake of norepinephrine. 2-Phenoxyethylamine can also block α1-receptors, but has no obvious effect on dopamine receptors. There was no significant antimuscarinic effect compared to other tricyclic antidepressants.
for the synthesis of naphthalazodone and other raw materials

Last Update：2024-04-09 21:01:54