2-Propene-1-amine
3-Amino-1-propene
CAS: 107-11-9
Molecular Formula: C3H7N
2-Propene-1-amine - Names and Identifiers
| Name | 3-Amino-1-propene |
| Synonyms | Allylamin ALLYLAMINE Allylamine 3-Aminopropen 4-04-00-01057 3-Aminopropene 2-Propenylamine 3-Aminopropylene 2-Propene-1-amine prop-1-en-2-amine 1-Aminoprop-2-ene prop-2-en-1-amine 3-Amino-1-propene 2-Propen-1-ylamin 3-AMINO-1-PROPENE |
| CAS | 107-11-9 |
| EINECS | 203-463-9 |
| InChI | InChI=1/C3H7N/c1-3(2)4/h1,4H2,2H3 |
2-Propene-1-amine - Physico-chemical Properties
| Molecular Formula | C3H7N |
| Molar Mass | 57.09 |
| Density | 0.761 g/mL at 25 °C (lit.) |
| Melting Point | -88 °C (lit.) |
| Boling Point | 53 °C (lit.) |
| Flash Point | −20°F |
| Water Solubility | miscible |
| Solubility | miscible with water, alcohol, chloroform and ether |
| Vapor Presure | 4.09 psi ( 20 °C) |
| Vapor Density | 2 (vs air) |
| Appearance | Crystalline or Granular Powder |
| Color | White or almost white |
| Merck | 14,287 |
| BRN | 635703 |
| pKa | 9.49(at 25℃) |
| Storage Condition | Flammables area |
| Stability | Stability Air sensitive. Serious fire hazard. Highly flammable - note low flash point. May be ignited at temperatures close to ambient. |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.420(lit.) |
| Physical and Chemical Properties | Colorless liquid. Melting Point -88 °c, boiling point 58 °c, relative density 0.7621(20/4 °c), refractive index 1.4205, flash point 28 °c. Miscible with water, alcohol, chloroform and ether. There is a strong ammonia and scorching odor. |
| Use | Used as pharmaceutical intermediates, emulsion modifiers, organic synthesis and resin modifiers, silicon products and other intermediates |
2-Propene-1-amine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S9 - Keep container in a well-ventilated place. S16 - Keep away from sources of ignition. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2334 6.1/PG 1 |
| WGK Germany | 2 |
| RTECS | BA5425000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29211980 |
| Hazard Class | 6.1 |
| Packing Group | I |
| Toxicity | LD50 i.p. in mice: 49 mg/kg (Hine) |
2-Propene-1-amine - Reference Information
| LogP | 0.13 at 20℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | allylamine is an important raw material or intermediate product for the synthesis of many drugs. It is an extremely flammable liquid. Toxic, corrosive. Uses: Used in pharmaceutical intermediates, as well as agricultural chemicals, diuretics, emulsion modifiers, organic synthesis and resin modifiers, silicon products and other intermediates. There are reports that it can polymerize with plasma to form reverse osmosis polymers, which can be used in closed manned spacecraft; it can also be used as corrosion inhibitors, catalysts and solvents. |
| Synthesis method | The synthesis method of allylamines is free radical polymerization. 1. monomer molecular polymerization. Figure 1 shows the polymerization route of allylamine monomer. 2, triallylamine polymerization. Figure 2 shows the polymerization route of triallylamine. 3, chiral allylamine polymerization. Figure 3 shows the chiral allylamine polymerization route. the synthesis of chiral allylamine has become one of the hot topics in research. Using this reaction to synthesize chiral monosubstituted allylamines, fully substituted allylamines, cyclic allylamines and other reports continue to emerge, more and more chiral ligands are designed and synthesized, and the reaction conditions are becoming more and more mild. However, in this reaction, the catalyst is expensive and the synthesis process of chiral ligands is redundant. Starting from the principles of atomic economy and environmental friendliness, it can be predicted that recyclable catalysts, chiral ligands and green solvents (water, supercritical carbon dioxide, ionic liquids) will become new research directions. |
| first aid | eyes: immediately rinse with sufficient water for at least 15 minutes. You can hold up the upper and lower eyelids with your fingers and seek medical help immediately. Victims are never allowed to rub their eyes or make their eyes golden. Skin: Seek medical assistance immediately. Rinse the skin with sufficient water for at least 15 minutes while removing contaminated clothes and shoes. Ingestion: Don't force yourself to vomit. If the victim is still conscious, drink 2 to 4 full cups of milk water. But never give the unconscious victim anything through the mouth. Seek medical assistance right away. Inhalation: Seek medical assistance immediately. Turn it into a zone of fresh air as soon as possible. If you cannot breathe, you should perform artificial respiration; if you have difficulty breathing, you should inject oxygen. |
| fire extinguishing | once a fire breaks out, fire extinguishing personnel need to wear full-body protective clothing with self-breathing devices. Its vapor mixed with air can form an explosion. The vapor can also spread to the fire source and then burn back. And combustion can form toxic gases. Water needs to be sprinkled to keep the storage tank cool. Both its liquid and its gas are extremely easy to burn. Its vapor is heavier than air, so it is very easy to spread along the ground, at the lower level. It is very easy to burn when exposed to heat, Mars and flames. The storage tank may explode when it encounters heat. Fire extinguishing equipment: If the fire is small, use dry powder, carbon dioxide, sprinkler, and soluble foam to extinguish the fire. If the fire is large, use water, mist or soluble foam to extinguish the fire. |
| leak emergency treatment | follow the following: use the correct personal protection equipment. Leakage: Use inert materials to absorb leaked items (such as vermiculite and sand), and then place them in appropriate storage tanks. Transfer all sources of fire. Vapor suppression foam can be used to reduce its vapor. Sprinkling water can reduce steam, but if it is in a more enclosed space, it cannot stop the fire source. operation processing and storage editing precautions for operation: airtight operation, strengthen ventilation. Operators must undergo special training and strictly abide by the operating procedures. It is recommended that operators wear self-priming filter gas masks (full masks), anti-static overalls and rubber oil-resistant gloves. Stay away from fire and heat sources. Smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent vapor from leaking into the workplace air. Avoid contact with oxidants and acids. Filling should control the flow rate to prevent static electricity accumulation. When handling, it should be lightly loaded and unloaded to prevent damage to the packaging and containers. Equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Empty containers may remain harmful substances. storage precautions: store in a cool and ventilated warehouse. Stay away from fire and heat sources. The reservoir temperature should not exceed 30 ℃. The packaging is required to be sealed and not in contact with air. It should be stored separately from oxidants, acids and edible chemicals, and should not be mixed. Explosion-proof lighting and ventilation facilities are adopted. It is forbidden to use mechanical equipment and tools that are prone to spark. The storage area shall be equipped with leakage emergency treatment equipment and suitable storage materials. The "five pairs" management system for extremely toxic substances should be strictly implemented. |
| References | [1] Ding Lei. Research on a new method for the synthesis of high allylamine compounds [D]. Shanghai Normal University, 2014. [2] Lu Beisheng. Synthesis and Application of Allylamine Copolymers in Separation [D]. Tianjin University of Science and Technology, 2009. [3] Luo Jie, Jiang Huanfeng. Progress in Synthesis of Chiral Allylamine [J]. Organic Chemistry, 2008,(02):187-193. [4] Tang Bingtao, Zhang Shufen, Yang Jinzong, Liu Feng. Study on Synthesis of Allylamine [J]. Journal of Dalian University of Technology, 2004,(02):224-227. |
| use | used in organic synthesis, resin and diuretic. Used as intermediates for pharmaceutical intermediates, emulsion modifiers, organic synthesis and resin modifiers, silicon products, etc. intermediates for the production of pharmaceuticals, agricultural chemicals, emulsion modifiers and plastic additives. |
| production method | allyl chloride reacts with ammonia to produce allylamine: the reaction is carried out in a device with a reflux device to make propylene thioisocyanate react with 20% hydrochloric acid reflux for 15h. The reactants are concentrated, and when the crystallization appears, water is added to dilute it, and then allylamine is evaporated while adding lye dropwise. The collected crude products can be refined by fractionation. |
| category | flammable liquid |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 102 mg/kg; Oral-mouse LD50: 57 mg/kg |
| stimulation data | skin-rabbit 500 mg/24 hours severe; Eye-rabbit 50 mg/20 seconds severe |
| explosive hazard characteristics | blastable when mixed with air |
| flammability hazard characteristics | flammable in case of open flame, high temperature and oxidant; toxic nitrogen oxide smoke from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidants and acids; It is not suitable to store for a long time to prevent polymerization |
| fire extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent |
| occupational standard | TWA 5 mg/m3; STEL 15 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:47
