2-Pyridinamine,5-(1-methyl-2-pyrrolidinyl)-,dihydrochloride
5-(1-Methyl-pyrrolidin-2-yl)-pyridin-2-ylaminedihydrochloride
CAS: 104395-87-1
Molecular Formula: C10H16ClN3
2-Pyridinamine,5-(1-methyl-2-pyrrolidinyl)-,dihydrochloride - Names and Identifiers
2-Pyridinamine,5-(1-methyl-2-pyrrolidinyl)-,dihydrochloride - Physico-chemical Properties
| Molecular Formula | C10H16ClN3 |
| Molar Mass | 213.71 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD09475402 |
2-Pyridinamine,5-(1-methyl-2-pyrrolidinyl)-,dihydrochloride - Risk and Safety
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| Hazard Class | IRRITANT |
2-Pyridinamine,5-(1-methyl-2-pyrrolidinyl)-,dihydrochloride - Introduction
5-(Ti)-pyridin-2-ylaminedihydrochloride is an organic compound. Its chemical formula is C12H17Cl2N3 and has two hydrochloride salt groups.
The following is a description of its nature, use, method and safety information:
Nature:
-Appearance: White to off-white crystalline solid.
-Melting point: about 150-155°C.
-Solubility: easy to dissolve in warm water and acidic environment, but low solubility in ethanol, ether and petroleum ether.
Use:
- 5-pyridin-2-ylaminedihydrochloride can be used as pharmaceutical intermediates.
-It can be used as a condensing agent during the synthesis of ticagrelor (Tegaserod).
Preparation Method:
-5-(1-methylpyrrolidin-2-yl) pyridine can be generated by the reaction of dimethylammonia and 2-bromo-5-(1-methylpyrrolidin-2-yl) pyridine.
-Next, 5-(1-methylpyrrolidin-2-yl) pyridine is reacted with hydrochloric acid to obtain 5-(1-methylpyrrolidin-2-yl) pyridine hydrochloride.
-Finally, 5-(1-methylpyrrolidin-2-yl) pyridine hydrochloride was further reacted with 2-cyanopyridine to prepare 5-(1-methylpyrrolidin-2-yl)-2-(pyridin-2-yl) ethylamine, which was then treated with hydrochloric acid to prepare 5-(5-methylpyrrolidin-2-yl)-pyridin-2-ylaminedihydrochloride.
Safety Information:
- 5-(skin)-pyridin-2-ylaminedihydrochloride may cause irritation to the eyes, respiratory tract, so pay attention to the use of personal protective equipment during operation.
-It should be stored in a dry, cool place and avoid contact with oxidizing agents.
-Observe appropriate chemical laboratory practices and safe operating procedures when using or handling the substance.
The following is a description of its nature, use, method and safety information:
Nature:
-Appearance: White to off-white crystalline solid.
-Melting point: about 150-155°C.
-Solubility: easy to dissolve in warm water and acidic environment, but low solubility in ethanol, ether and petroleum ether.
Use:
- 5-pyridin-2-ylaminedihydrochloride can be used as pharmaceutical intermediates.
-It can be used as a condensing agent during the synthesis of ticagrelor (Tegaserod).
Preparation Method:
-5-(1-methylpyrrolidin-2-yl) pyridine can be generated by the reaction of dimethylammonia and 2-bromo-5-(1-methylpyrrolidin-2-yl) pyridine.
-Next, 5-(1-methylpyrrolidin-2-yl) pyridine is reacted with hydrochloric acid to obtain 5-(1-methylpyrrolidin-2-yl) pyridine hydrochloride.
-Finally, 5-(1-methylpyrrolidin-2-yl) pyridine hydrochloride was further reacted with 2-cyanopyridine to prepare 5-(1-methylpyrrolidin-2-yl)-2-(pyridin-2-yl) ethylamine, which was then treated with hydrochloric acid to prepare 5-(5-methylpyrrolidin-2-yl)-pyridin-2-ylaminedihydrochloride.
Safety Information:
- 5-(skin)-pyridin-2-ylaminedihydrochloride may cause irritation to the eyes, respiratory tract, so pay attention to the use of personal protective equipment during operation.
-It should be stored in a dry, cool place and avoid contact with oxidizing agents.
-Observe appropriate chemical laboratory practices and safe operating procedures when using or handling the substance.
Last Update：2024-04-09 21:00:56
