2-Pyrimidinamine,5-fluoro-(9CI)

2-Pyrimidinamine,5-fluoro-(9CI) - Names and Identifiers

Name	2-Pyrimidinamine,5-fluoro-(9CI)
Synonyms	5-fluoropyriMidin-2-aMine 5-Fluoro-2-pyrimidinamine 2-AMINO-5-FLUOROPYRIMIDINE 2-PyriMidinaMine,5-fluoro- Amino-5-fluoropyrimidine,2- 2-Pyrimidinamine,5-fluoro-(9CI) 2-Pyrimidinamine, 5-fluoro- (9CI) 5-Fluoropyrimidin-2-amine, Fandachem 5-Fluoropyrimidin-2-amine, 2-Amino-5-fluoro-1,3-diazine
CAS	1683-85-8
InChI	InChI=1/C4H4FN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8)

2-Pyrimidinamine,5-fluoro-(9CI) - Physico-chemical Properties

Molecular Formula	C4H4FN3
Molar Mass	113.09
Density	1.372
Melting Point	192-193℃
Boling Point	280℃
Flash Point	123℃
pKa	2.13±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.56

2-Pyrimidinamine,5-fluoro-(9CI) - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

2-Pyrimidinamine,5-fluoro-(9CI) - Reference Information

Use

2-amino-5-fluoropyrimidine can be used as a synthetic intermediate in pharmaceutical and chemical industry.

preparation

the preparation of 2-amino-5-fluoropyrimidine is as follows: 2-chloro-5-fluoropyrimidine (280 μL, 2.264mmol) and ammonia (5ml,68mmol) in methanol (860 μL) the mixture was heated to 110 °c for 30 min through a microwave reactor. The reaction was filtered and the solid was washed with MeOH. The solid was dried to give 5-fluoro-2-pyrimidinamine (247mg,2.184mmol,96% yield) as a white crystalline solid.

Last Update：2024-04-09 19:05:05