2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA

2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA - Names and Identifiers

Name	2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA
Synonyms	2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA O-tert-Butyl-N,N'-diisopropylisourea tert-Butyl N,N'-diisopropylcarbaMiMidate tert-Butyl N,N'-diisopropylimidocarbamate tert-butyl N,N'-bis(1-methylethyl)imidocarbamate CarbaMiMidic acid, N,N'-bis(1-Methylethyl)-, 1,1-diMethylethyl ester
CAS	71432-55-8

2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA - Physico-chemical Properties

Molecular Formula	C11H24N2O
Molar Mass	200.32
Density	0.89±0.1 g/cm3(Predicted)
Boling Point	61°C/10mmHg(lit.)
pKa	9.54±0.50(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
Refractive Index	1.4240-1.4280
Use	Uses O-tert-butyl-N,N'-diisopropylisourea is a useful synthetic intermediate for the synthesis of 5-Oxo atorvastatin tert-butyl ester, which is a Boc-protected derivative of atorvastatin. O-tert-butyl-N,N'-diisopropylisourea is also used as a total synthetic reagent for the antifungal natural product sitrafengin A.

2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA - Upstream Downstream Industry

Raw Materials	tert-Butanol N,N'-Diisopropylcarbodiimide
Downstream Products	N-1-Boc-amino-3-cyclopentene 2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA

2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA - Preparation

at room temperature, the mixture of DIC(2.52 g1.0eq.) and tert-butanol (1.8 g1.2eq.) is placed in a round-bottomed flask and a catalytic amount of CuCl is added, and then the reaction system is replaced by N2 protection. Stir for 4 days to obtain the crude dark green compound as described in the title, which is directly used for the next reaction.

Last Update：2024-04-10 22:29:15