2-TRIMETHYLSILYTHIAZOLE
2-(Trimethylsilyl)thiazole
CAS: 79265-30-8
Molecular Formula: C6H11NSSi
2-TRIMETHYLSILYTHIAZOLE - Names and Identifiers
2-TRIMETHYLSILYTHIAZOLE - Physico-chemical Properties
| Molecular Formula | C6H11NSSi |
| Molar Mass | 157.31 |
| Density | 0.985g/mLat 25°C(lit.) |
| Boling Point | 56-57°C10mm Hg(lit.) |
| Flash Point | 135°F |
| Water Solubility | IMMISCIBLE |
| Solubility | THF: very soluble(lit.) |
| Appearance | Liquid |
| Specific Gravity | 0.99 |
| Color | Clear colorless to slightly yellow |
| BRN | 3538017 |
| pKa | 2.91±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | 7: reacts slowly with moisture/water |
| Refractive Index | n20/D 1.497(lit.) |
2-TRIMETHYLSILYTHIAZOLE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 1993 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29341000 |
| Hazard Class | 3 |
| Packing Group | III |
2-TRIMETHYLSILYTHIAZOLE - Introduction
2-(Trimethylsilyl)thiazole is an organic compound with the chemical formula C7H15NSi. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 2-(Trimethylsilyl)thiazole is a colorless to light yellow liquid.
-Melting point and boiling point: Its melting point is between -55°C and -54°C, and its boiling point is about 134°C.
-Solubility: Soluble in most organic solvents, such as ether, chlorinated hydrocarbons and alcohols.
Use:
- 2-(Trimethylsilyl)thiazole is often used as an intermediate in organic synthesis. It can act as a catalyst and participate in many chemical reactions, for example in the silylation of olefins.
-Due to its catalytic properties and reactivity, it is also often used as a hydrogenation reagent, a reducing agent and an aryl deprotection reagent.
Preparation Method:
- 2-(Trimethylsilyl)thiazole can be prepared by introducing a trimethylsilyl group into a thiazole compound. The commonly used preparation method is to use 3-propanesulfonylthiazole and trimethylsilylcupric chloride as raw materials to react under alkaline conditions to generate 2-(Trimethylsilyl)thiazole.
Safety Information:
-Used under correct operation, 2-(Trimethylsilyl)thiazole has no clear toxicity. However, like all chemicals, appropriate precautions should be taken to avoid contact with skin, eyes and inhalation during handling.
-When storing and handling, it should be stored in a sealed container to avoid contact with oxygen and moisture to avoid possible dangerous situations.
Nature:
-Appearance: 2-(Trimethylsilyl)thiazole is a colorless to light yellow liquid.
-Melting point and boiling point: Its melting point is between -55°C and -54°C, and its boiling point is about 134°C.
-Solubility: Soluble in most organic solvents, such as ether, chlorinated hydrocarbons and alcohols.
Use:
- 2-(Trimethylsilyl)thiazole is often used as an intermediate in organic synthesis. It can act as a catalyst and participate in many chemical reactions, for example in the silylation of olefins.
-Due to its catalytic properties and reactivity, it is also often used as a hydrogenation reagent, a reducing agent and an aryl deprotection reagent.
Preparation Method:
- 2-(Trimethylsilyl)thiazole can be prepared by introducing a trimethylsilyl group into a thiazole compound. The commonly used preparation method is to use 3-propanesulfonylthiazole and trimethylsilylcupric chloride as raw materials to react under alkaline conditions to generate 2-(Trimethylsilyl)thiazole.
Safety Information:
-Used under correct operation, 2-(Trimethylsilyl)thiazole has no clear toxicity. However, like all chemicals, appropriate precautions should be taken to avoid contact with skin, eyes and inhalation during handling.
-When storing and handling, it should be stored in a sealed container to avoid contact with oxygen and moisture to avoid possible dangerous situations.
Last Update：2024-04-10 22:29:15
