2-Trifluoromethyl-3-nitro-pyridine

2-Trifluoromethyl-3-nitro-pyridine - Names and Identifiers

Name	3-nitro-2-(trifluoromethyl)pyridine
Synonyms	2-Trifluoromethyl-3-nitro-pyridine 3-nitro-2-(trifluoromethyl)pyridine 3-Nitro-2-(trifluoromethyl)pyridine
CAS	133391-63-6
InChI	InChI=1S/C6H3F3N2O2/c7-6(8,9)5-4(11(12)13)2-1-3-10-5/h1-3H

2-Trifluoromethyl-3-nitro-pyridine - Physico-chemical Properties

Molecular Formula	C6H3F3N2O2
Molar Mass	192.1
Density	1.500
Boling Point	214℃
Flash Point	83℃
Storage Condition	2-8°C

2-Trifluoromethyl-3-nitro-pyridine - Introduction

2-Trifluoromethyl-3-nitropyridine (-) is an organic compound with the chemical formula of C6H3F3N2O2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 2-Trifluoromethyl-3-nitropyridine as a white crystalline solid.
-Melting point: about 60-62 degrees Celsius.
-Boiling point: about China 105 degrees Celsius.
-Density: about 1.62g/cm³.
-Solubility: Soluble in organic solvents such as ethanol, ether and ketone.

Use:
-2-trifluoromethyl-3-nitropyridine is commonly used in the synthesis of drugs or pesticide intermediates, and has important application value.

Preparation Method:
At present, the more commonly used preparation method is obtained by reacting 2-amino -3-boronic acid pyridine with a trifluoromethylation reagent. The specific process is as follows:
1.2-amino -3-boronic acid pyridine and trifluoromethylation reagent are reacted under the action of an organic solvent.
2. After the reaction is completed, 2-trifluoromethyl-3-nitropyridine product is obtained by distillation and crystallization purification.

Safety Information:
-2-trifluoromethyl-3-nitropyridine should pay attention to fire prevention and static electricity accumulation during storage and operation to avoid fire and explosion.
-Contact with skin or inhalation of its vapors may cause irritation and injury. Contact with skin and inhalation of vapors should be avoided, and appropriate gloves and protective masks should be worn when necessary.
-In use and storage, should comply with the relevant safety procedures, avoid mixing with oxidants and combustibles.
-Pay attention to environmental protection during processing and comply with relevant national laws and regulations.

Please note that when using and handling any chemical substances, correct laboratory operating procedures should be followed and safe operating procedures should be followed.

Last Update：2024-04-09 15:17:51