2-amino-5-(trifluoromethyl)phenol

2-amino-5-(trifluoromethyl)phenol - Names and Identifiers

Name	Phenol, 2-amino-5-(trifluoromethyl)-
Synonyms	2-amino-5-(trifluoromethyl)phenol 2-Amino-5-(trifluoromethyl)phenol 2-Hydroxy-4-(Trifluoromethyl)Aniline 2-HYDROXY-4-(TRIFLUOROMETHYL)ANILINE Phenol, 2-amino-5-(trifluoromethyl)- 2-Hydroxy-4-(trifluoromethyl)aniline, 4-Amino-3-hydroxybenzotrifluoride 2-Hydroxy-4-(trifluoromethyl)aniline, 2-Amino-5-(trifluoromethyl)phenol
CAS	454-82-0
EINECS	200-258-5

2-amino-5-(trifluoromethyl)phenol - Physico-chemical Properties

Molecular Formula	C7H6F3NO
Molar Mass	177.12
Density	1.432±0.06 g/cm3(Predicted)
Melting Point	>350 °C
Boling Point	233.8±40.0 °C(Predicted)
Flash Point	95.2 °C
pKa	8.75±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

2-amino-5-(trifluoromethyl)phenol - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

2-amino-5-(trifluoromethyl)phenol - Introduction

Phenol, 2-amino-5-(trifluoromethyl)-is an organic compound with the chemical formula C6H4F3NO.

Nature:
-Appearance: Colorless crystalline solid.
-Melting point: 121-124°C.
-Boiling point: 220-222°C.
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and dimethylformamide.

Use:
-as an important intermediate in organic synthesis, participate in the synthesis of fluorescent dyes and pharmaceutical compounds.
-In the pharmaceutical field, it can be used to synthesize anti-cancer drugs and anti-diabetic drugs.
-in the field of pesticides, can be used for synthetic pesticides.

Preparation Method:
A common preparation method is obtained by reacting phenol with a fluoroformate. Specific steps are as follows:
1. take phenol and trifluoroformate reaction in organic solvent, adding appropriate amount of catalyst.
2. reaction produces Phenol, 2-amino-5-(trifluoromethyl)-, which is purified by crystallization and purification.

Safety Information:
- Phenol, 2-amino-5-(trifluoromethyl)-Be careful to avoid contact with skin, eyes and respiratory tract during use.
-Wear protective gloves, goggles and respiratory protection during operation.
-In case of contact, rinse immediately with plenty of water.
-Specific safety handling and storage recommendations can be found in the safety data sheet of the compound.

Last Update：2024-04-09 19:05:50