2-amino-5-hydroxypryidine
2-aminopyridin-5-ol
CAS: 55717-46-9
Molecular Formula: C5H6N2O
2-amino-5-hydroxypryidine - Names and Identifiers
2-amino-5-hydroxypryidine - Physico-chemical Properties
| Molecular Formula | C5H6N2O |
| Molar Mass | 110.11 |
| Density | 1.320±0.06 g/cm3(Predicted) |
| Melting Point | 116-117 °C(Solv: methanol (67-56-1); benzene (71-43-2)) |
| Boling Point | 447.4±30.0 °C(Predicted) |
| pKa | 10.47±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
2-amino-5-hydroxypryidine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
2-amino-5-hydroxypryidine - Reference Information
| Properties | 2-Amino-5-hydroxypyridine (2-Amino-5-hydroxypyridine), also known as 3-amino-3-pyridine, its molecular formula is C5H6N2O, The molecular weight is 110.11, the CAS number is 55717-46-9, the melting point is 116-117 oC, and it is a light yellow crystal at room temperature. It is an important pharmaceutical intermediate. |
| Uses | 2-amino-5-hydroxypyridine is a pyridine compound. Due to its structure with active amino and hydroxyl groups, it is an important pharmaceutical intermediate and is widely used in drugs such as hypertension and kidney agonists. |
| synthesis method | 2-amino -5-hydroxypyridine commonly used synthesis methods are as follows: 1) diazo method: the synthesis route is shown in the following figure. this method uses diazo method to introduce hydroxyl group, which is dangerous in operation, long in reaction steps and not easy to enlarge. Halogen substitution method: 2-amino-5-bromopyridine is used to react with sodium methoxide under high pressure to obtain the intermediate 2-amino-5-methoxypyridine; the intermediate can be demethylated with boron tribromide The target product (2-amino-5-hydroxypyridine) is obtained, but the separation yield is very low. 3) Amino-protected halogen substitution method: This method is 2-amino-5-iodopyridine as the raw material. After the amino is protected, it can react with sodium methoxide under normal conditions, and then remove the amino protection group to obtain the intermediate 2-Amino-5-methoxypyridine. The intermediate still needs to be demethylated with boron tribromide to obtain the target product, but the separation yield is very low. |
Last Update：2024-04-09 21:01:54
