2-azanyl-5-fluoro-phenol
2-Amino-5-fluorophenol
CAS: 53981-24-1
Molecular Formula: C6H6FNO
2-azanyl-5-fluoro-phenol - Names and Identifiers
| Name | 2-Amino-5-fluorophenol |
| Synonyms | 2-AMINO-5-FLUOROPHEN 2-AMINO-5-FLUOROPHENOL 2-Amino-5-fluorophenol 2-azanyl-5-fluoro-phenol 4-Fluoro-2-hydroxyaniline 3-[6-(trifluoromethyl)pyridin-3-yl]propanoic acid |
| CAS | 53981-24-1 |
| InChI | InChI=1/C9H8F3NO2/c10-9(11,12)7-3-1-6(5-13-7)2-4-8(14)15/h1,3,5H,2,4H2,(H,14,15) |
2-azanyl-5-fluoro-phenol - Physico-chemical Properties
| Molecular Formula | C6H6FNO |
| Molar Mass | 127.12 |
| Density | 1.347±0.06 g/cm3(Predicted) |
| Melting Point | 38°C |
| Boling Point | 246.1±25.0 °C(Predicted) |
| Flash Point | 133.1°C |
| Water Solubility | Slightly soluble in water. |
| Solubility | DMSO, Methanol |
| Vapor Presure | 0.000642mmHg at 25°C |
| Appearance | Solid |
| Color | Dark Beige |
| pKa | 8.76±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Air Sensitive |
| Refractive Index | 1.474 |
| Physical and Chemical Properties | Brown-red solid |
2-azanyl-5-fluoro-phenol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| HS Code | 29089990 |
| Hazard Class | IRRITANT |
2-azanyl-5-fluoro-phenol - Reference Information
| introduction | 2-amino-5-fluorophenol is an organic intermediate, which can be prepared from 2, 4-difluoroaniline in one step. 2, 4-difluoroaniline can be used to prepare the intermediate 7-fluoro-6-amino-2H-1, 4-benzoxazine-3 (4H)-one of propargeneflumine. |
| preparation method | a certain amount of 2,4-difluoroaniline, water and potassium hydroxide are successively put into the reaction kettle, the temperature naturally rises to 50-80 degrees, the temperature is kept at 50-80 degrees for about 4-5 hours, the temperature is kept at 60 minutes after adding, and the sampling is less than 0.5%. After sampling is qualified, add a certain amount of hydrochloric acid, the product is added and the water is azeotropic, stirred evenly, heated and heated, and the product is steamed out by steam distillation; after distillation, 2-amino -5-fluorophenol is obtained. |
Last Update：2024-04-10 22:29:15
