2-bromo-1-(3,4-difluorophenyl)ethanone

2-bromo-1-(3,4-difluorophenyl)ethanone - Names and Identifiers

Name	3,4-difluorophenacyl bromide
Synonyms	BUTTPARK 351-53 3,4-difluorophenacyl bromide 3,4-DIFLUOROPHENACYL BROMIDE 3',4'-DIFLUOROPHENACYL BROMIDE 2-Bromo-3,4-difluoroacetophenone 2-BROMO-3',4'-DIFLUOROACETOPHENONE 2-bromo-3',4'-difluoroacetophenone 2-bromo-1-(3,4-difluorophenyl)ethanone 2-Bromo-1-(3,4-difluorophenyl)ethan-1-one 2-BROMO-1-(3,4-DIFLUOROPHENYL)ETHAN-1-ONE 3,4-difluorophenacyl bromide ,2-bromo-1-(3,4-dichlorophenyl)ethanone
CAS	40706-98-7
InChI	InChI=1/C8H5BrF2O/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3H,4H2

2-bromo-1-(3,4-difluorophenyl)ethanone - Physico-chemical Properties

Molecular Formula	C8H5BrF2O
Molar Mass	235.03
Density	1.648±0.06 g/cm3(Predicted)
Melting Point	28 °C
Boling Point	261.0±25.0 °C(Predicted)
Flash Point	110 °C
Vapor Presure	0.0119mmHg at 25°C
Storage Condition	2-8℃
Refractive Index	1.529

2-bromo-1-(3,4-difluorophenyl)ethanone - Risk and Safety

Risk Codes	R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	3261
HS Code	29147000
Hazard Note	Flammable/Corrosive
Hazard Class	CORROSIVE

2-bromo-1-(3,4-difluorophenyl)ethanone - Introduction

3,4-difluorophenacyl bromide, also known as 3,4-difluoroacetophenyl bromide, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Colorless or light yellow liquid.
-Solubility: Soluble in organic solvents such as ether, chloroform and dimethyl sulfoxide.
-Melting point: approximately -12°C.
-Boiling point: about 150-155°C.
-Molecular formula: C9H6BrF2O.

Use:
- 3,4-difluorophenacyl bromide is widely used in the field of organic synthesis, especially as a deprotection reagent for carboxylic acid protecting groups.
-It can be used to synthesize precursor compounds of coumarin derivatives, which have pharmaceutical and biological activities.
-It can also be used to synthesize heterocyclic compounds and organometallic compounds.

Preparation Method:
3,4-difluorophenacyl bromide is generally prepared by the following steps:
1. Dissolve 3,4-difluoroacetophenone in an appropriate solvent.
2. Add bromide to solution.
3. The reaction is carried out under appropriate conditions, usually by heating the reaction mixture.

Safety Information:
3,4-difluorophenacyl bromide is an organic compound that needs to be operated with appropriate safe operating procedures.
-Wear appropriate protective gloves, goggles and protective clothing during handling and contact.
-Avoid inhalation and ensure that the operation is carried out in a well-ventilated place.
-Avoid contact with skin and eyes, and rinse with plenty of water immediately after contact.
-Please follow the correct process conditions and operating methods when using.
-Be careful in handling and storage to avoid contact with oxidants, strong acids, strong bases and other substances.

Last Update：2024-04-09 02:00:45