2-bromo-1-(5-chloro-2-hydroxyphenyl)ethanone
2-bromo-1-(5-chloro-2-hydroxyphenyl)ethanone
CAS: 52727-99-8
Molecular Formula: C8H6BrClO2
2-bromo-1-(5-chloro-2-hydroxyphenyl)ethanone - Names and Identifiers
| Name | 2-bromo-1-(5-chloro-2-hydroxyphenyl)ethanone |
| Synonyms | 2-bromo-1-(5-chloro-2-hydroxyphenyl)ethanone Ethanone, 2-bromo-1-(5-chloro-2-hydroxyphenyl)- |
| CAS | 52727-99-8 |
| InChI | InChI=1/C8H6BrClO2/c9-4-8(12)6-3-5(10)1-2-7(6)11/h1-3,11H,4H2 |
2-bromo-1-(5-chloro-2-hydroxyphenyl)ethanone - Physico-chemical Properties
| Molecular Formula | C8H6BrClO2 |
| Molar Mass | 249.49 |
| Density | 1.726±0.06 g/cm3(Predicted) |
| Melting Point | 63-67°C |
| Boling Point | 320.9±32.0 °C(Predicted) |
| Flash Point | 147.8°C |
| Vapor Presure | 0.000165mmHg at 25°C |
| pKa | 7.05±0.43(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.62 |
2-bromo-1-(5-chloro-2-hydroxyphenyl)ethanone - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
2-bromo-1-(5-chloro-2-hydroxyphenyl)ethanone - Introduction
2-bromo-1-(ethanone) is an organic compound. It has a molecular formula of C10H8BrClO2 and a molecular weight of 259.53g/mol.
Nature:
2-bromo-1-(ethanone) is a solid with white to yellowish crystals. Its melting point ranges from 96-100 degrees Celsius. It is almost insoluble in water at room temperature, but soluble in organic solvents such as ethanol, chloroform and dimethyl sulfoxide.
Use:
2-bromo-1-(-) ethanone can be used in the synthesis of organic intermediates and pharmaceuticals. It can be used as a protective group of ketone or hydroxyl group in the synthesis process and participate in a series of chemical reactions. In addition, it can also be used in organic synthesis reagents and pharmaceutical research.
Preparation Method:
The synthesis of 2-bromo-1-(-) ethanone can usually be carried out by the following steps:
1. Using 5-chloro-2-hydroxybenzaldehyde as the starting material, the corresponding esterification product was obtained by esterification with bromoacetic acid.
2. the esterification product reacts with hydrobromic acid to generate 2-bromo-1-(-) ethanone.
3. The product is crystallized and purified to obtain the target product.
Safety Information:
2-bromo-1-(-) ethanone shall comply with relevant safety procedures during use and storage. Because it is a chemical, it is irritating and dangerous, and may cause health effects. Appropriate protective equipment should be worn during operation, and care should be taken to avoid contact with skin, eyes and respiratory tract. During storage, it should be kept away from fire sources, oxidants and strong acids and alkalis, and stored in a dry, clean and well-ventilated place.
Nature:
2-bromo-1-(ethanone) is a solid with white to yellowish crystals. Its melting point ranges from 96-100 degrees Celsius. It is almost insoluble in water at room temperature, but soluble in organic solvents such as ethanol, chloroform and dimethyl sulfoxide.
Use:
2-bromo-1-(-) ethanone can be used in the synthesis of organic intermediates and pharmaceuticals. It can be used as a protective group of ketone or hydroxyl group in the synthesis process and participate in a series of chemical reactions. In addition, it can also be used in organic synthesis reagents and pharmaceutical research.
Preparation Method:
The synthesis of 2-bromo-1-(-) ethanone can usually be carried out by the following steps:
1. Using 5-chloro-2-hydroxybenzaldehyde as the starting material, the corresponding esterification product was obtained by esterification with bromoacetic acid.
2. the esterification product reacts with hydrobromic acid to generate 2-bromo-1-(-) ethanone.
3. The product is crystallized and purified to obtain the target product.
Safety Information:
2-bromo-1-(-) ethanone shall comply with relevant safety procedures during use and storage. Because it is a chemical, it is irritating and dangerous, and may cause health effects. Appropriate protective equipment should be worn during operation, and care should be taken to avoid contact with skin, eyes and respiratory tract. During storage, it should be kept away from fire sources, oxidants and strong acids and alkalis, and stored in a dry, clean and well-ventilated place.
Last Update：2024-04-09 21:04:16
