2-bromo-1-ethanol

2-bromo-1-ethanol - Names and Identifiers

Name	2-Bromoethanol
Synonyms	BROMOETHANOL-2 2-BROMOETHANOL 1-bromoethanol 2-Bromoethanol 2-Bromo Ethenol 2-bromo-1-ethanol Ethylene bromohydrin ETHYLENE BROMOHYDRIN beta-Bromoethyl alcohol 2-Bromoethanol, (Ethylene bromohydrin)
CAS	540-51-2
EINECS	208-748-1
InChI	InChI=1/C2H5BrO/c1-2(3)4/h2,4H,1H3
InChIKey	LDLCZOVUSADOIV-UHFFFAOYSA-N

2-bromo-1-ethanol - Physico-chemical Properties

Molecular Formula	C2H5BrO
Molar Mass	124.96
Density	1.763 g/mL at 25 °C (lit.)
Melting Point	-80 °C
Boling Point	56-57 °C/20 mmHg (lit.)
Flash Point	>230°F
Water Solubility	1-5 g/100 mL at 19 ºC
Solubility	1-5 g/100 mL at 19°C
Vapor Presure	2.4 mm Hg ( 20 °C)
Vapor Density	4.3 (vs air)
Appearance	Liquid
Specific Gravity	1.7629 (20/4℃)
Color	Clear colorless to yellow
Merck	14,3792
BRN	878140
pKa	13.82±0.10(Predicted)
Storage Condition	2-8°C
Stability	Stable, but probably light sensitive. Hygroscopic. Incompatible with strong oxidizing agents. Flammable. Forms an azeotrope with water.
Sensitive	Light Sensitive
Refractive Index	n20/D 1.492(lit.)
Physical and Chemical Properties	Appearance of colorless or light yellow liquid boiling point 149-150 ℃
Use	Pharmaceutical Intermediates

2-bromo-1-ethanol - Risk and Safety

Risk Codes	R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R34 - Causes burns R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R10 - Flammable R67 - Vapors may cause drowsiness and dizziness R65 - Harmful: May cause lung damage if swallowed R48/20 - R38 - Irritating to the skin R11 - Highly Flammable R63 - Possible risk of harm to the unborn child
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - S16 - Keep away from sources of ignition. S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	UN 2922 8/PG 2
WGK Germany	3
RTECS	KJ8225000
TSCA	Yes
HS Code	29055900
Hazard Class	6.1
Packing Group	II

2-bromo-1-ethanol - Nature

Open Data Verified Data

colorless or yellowish hygroscopic liquid. Boiling point of 149~150 deg C (999 x l04 Pa decomposition). Relative density 1. 7629, refractive index 1. 49361. An aqueous solution has a sweet burning odor and can be mixed with water. Soluble in organic solvents other than petroleum ether. The aqueous solution was exposed to acid and heated,
Can accelerate the hydrolysis.

Last Update：2024-01-02 23:10:35

2-bromo-1-ethanol - Preparation Method

Open Data Verified Data

ethylene oxide was used as a raw material to react with hydrogen bromide, and the reaction solution was neutralized with sodium carbonate, extracted with diethyl ether, dried over anhydrous sodium sulfate, filtered, and distilled under reduced pressure.

Last Update：2022-01-01 10:15:37

2-bromo-1-ethanol - Use

Open Data Verified Data

used as solvent, organic chemical raw materials, Analytical reagents.

Last Update：2022-01-01 10:15:38

2-bromo-1-ethanol - Safety

Open Data Verified Data

toxic; Stronger than ethanol stimulation, General chlorine ethanol in the air maximum allowable concentration l6mg/m3. Rat LC32 x 10-6, guinea pig LD50. 11g/kg. Production equipment shall be closed, workshop shall be well ventilated, and staff shall wear protective equipment.
250ml glass bottle, external use wooden box or carton protection. Store in a cool, dry, ventilated warehouse. According to the general provisions of the storage and transportation of chemicals.

Last Update：2022-01-01 10:15:38

2-bromo-1-ethanol - Reference Information

NIST chemical information	Information provided by: webbook.nist.gov (external link)
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
use	used as solvent, organic chemical raw material and analytical reagent.
production method	obtained by the reaction of ethylene oxide and hydrogen bromide: ethylene oxide is introduced into 46%-48% hydrobromic acid solution at 0-20 ℃, and after the passage, the reaction is 1-2h. Neutralize hydrobromic acid with sodium carbonate at about 10 ℃, extract 2-bromoethanol with ether, dry the ether solution with anhydrous magnesium sulfate overnight, filter out the desiccant, and recover the ether to obtain the crude product. The finished product is obtained by decompression fractionation.
category	toxic substances
toxicity classification	highly toxic
acute toxicity	abdominal cavity-mouse LDL0: 80 mg/kg
flammability hazard characteristics	open flame is combustible; high heat emits toxic bromide gas
storage and transportation characteristics	warehouse ventilation and low temperature drying; Store separately from oxidants, acids and food additives
fire extinguishing agent	foam, carbon dioxide, sand, mist water