2-bromo-5-methylpyridin-4-amine - Names and Identifiers
2-bromo-5-methylpyridin-4-amine - Physico-chemical Properties
| Molecular Formula | C6H7BrN2
|
| Molar Mass | 187.05 |
| Density | 1.593±0.06 g/cm3(Predicted) |
| Melting Point | 125 °C |
| Boling Point | 332.2±37.0 °C(Predicted) |
| pKa | 5.26±0.42(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Irritant |
| MDL | MFCD11100653 |
| Use | Application 2-bromo-4-amino-5-methylpyrimidine can be used as an intermediate in organic synthesis and pharmaceutical intermediates for laboratory research and development and chemical production. |
2-bromo-5-methylpyridin-4-amine - Introduction
It is an organic compound with the molecular formula C6H7BrN2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless to light yellow crystal or crystalline powder.
-Solubility: It is soluble in common organic solvents (such as dimethyl sulfoxide, dimethylformamide, chloroform), but has low solubility in water.
-Melting point: Its melting point is about 133-135 ° C.
-Density: Its density is approximately 1.596g/cm³.
Use:
-Drug intermediate: It can be used as an intermediate for the synthesis of other drugs, and can be used to prepare chemicals and drugs in the pharmaceutical field.
-Organic synthesis: It can be used as a reagent in organic synthesis and participate in the synthesis of various organic compounds.
Method:
The preparation method can be carried out by the following steps:
1. Under alkaline conditions, 2-pyridyl -5-methyl pyridine (pyridine) is reacted with bromine to obtain 2-bromo-5-methyl pyridine (2-bromo-5-methylpyridine).
2. React the obtained 2-bromo-5-methylpyridine with amine to generate pyridine.
Safety Information:
-Irritating to skin and eyes, proper protective measures such as wearing gloves and goggles are required.
-During operation and storage, care should be taken to prevent it from contacting with oxidants to avoid dangerous reactions.
-This is a chemical that should comply with applicable safety procedures and be kept in a closed container, away from ignition sources and igniting substances.
-When using this compound, reasonable laboratory safety and hazardous waste disposal procedures should be followed.
Last Update：2024-04-09 02:00:51