2-chloro-1-fluoro-4-methoxybenzene
3-Chloro-4-fluoroanisole
CAS: 202925-07-3
Molecular Formula: C7H6ClFO
2-chloro-1-fluoro-4-methoxybenzene - Names and Identifiers
| Name | 3-Chloro-4-fluoroanisole |
| Synonyms | 3-CHLORO-4-FLUOROANISOLE 3-Chloro-4-fluoroanisole 2-chloro-1-fluoro-4-methoxybenzene 2-Chloro-1-fluoro-4-methoxybenzene Benzene, 2-chloro-1-fluoro-4-methoxy- |
| CAS | 202925-07-3 |
| InChI | InChI=1/C7H6ClFO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,1H3 |
2-chloro-1-fluoro-4-methoxybenzene - Physico-chemical Properties
| Molecular Formula | C7H6ClFO |
| Molar Mass | 160.57 |
| Density | 1,265 g/cm3 |
| Boling Point | 189°C |
| Flash Point | 79°C |
| Vapor Presure | 0.409mmHg at 25°C |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.515 |
| MDL | MFCD00070778 |
2-chloro-1-fluoro-4-methoxybenzene - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 1993 |
| Hazard Note | Irritant |
| Packing Group | III |
2-chloro-1-fluoro-4-methoxybenzene - Introduction
3-choro-4-fluoroanisole (Iso) is an organic compound with the chemical formula C7H6ClFO. The following is a description of some of the properties, uses, preparation and safety information of the compound:
Nature:
1. Appearance: 3-Chloro-4-fluoroanisole is a colorless to light yellow liquid.
2. Melting Point:-25.5 ° C
3. Boiling Point: 186-187 C
4. Density: 1.21g/cm³
5. Solubility: Soluble in organic solvents such as ethanol, ether, chlorinated methane and dichloromethane, insoluble in water.
Use:
1. 3-Chloro-4-fluoroanisole can be used as a reagent in organic synthesis and is commonly used in esterification, acylation and condensation reactions.
2. It is also used in the synthesis of intermediates in the fields of pesticides, medicine and coatings.
Method:
The preparation method of 3-Chloro-4-fluoroanisole can be carried out by the following steps:
1. Reacting methylene magnesium chloride (CH2ClMgCl) with 2-chloro-3-fluorotoluene to prepare 3-chloro-4-fluorobenzyl alcohol.
2. 3-chloro-4-fluorobenzyl alcohol is reacted with ether compounds such as methyl cyclohexyl ether under alkaline conditions to obtain 3-Chloro-4-fluoroanisole.
Safety Information:
1. 3-choro-4-fluoroanisole needs to pay attention to prevent fire and static electricity accumulation during use and storage to avoid fire or explosion.
2. Avoid contact with strong oxidants and strong bases to avoid hazardous substances.
3. After personal contact, rinse immediately with plenty of water and seek medical help.
4. 3-choro-4-fluoroanisole has certain toxicity to the environment, and attention should be paid to environmental protection during use.
Nature:
1. Appearance: 3-Chloro-4-fluoroanisole is a colorless to light yellow liquid.
2. Melting Point:-25.5 ° C
3. Boiling Point: 186-187 C
4. Density: 1.21g/cm³
5. Solubility: Soluble in organic solvents such as ethanol, ether, chlorinated methane and dichloromethane, insoluble in water.
Use:
1. 3-Chloro-4-fluoroanisole can be used as a reagent in organic synthesis and is commonly used in esterification, acylation and condensation reactions.
2. It is also used in the synthesis of intermediates in the fields of pesticides, medicine and coatings.
Method:
The preparation method of 3-Chloro-4-fluoroanisole can be carried out by the following steps:
1. Reacting methylene magnesium chloride (CH2ClMgCl) with 2-chloro-3-fluorotoluene to prepare 3-chloro-4-fluorobenzyl alcohol.
2. 3-chloro-4-fluorobenzyl alcohol is reacted with ether compounds such as methyl cyclohexyl ether under alkaline conditions to obtain 3-Chloro-4-fluoroanisole.
Safety Information:
1. 3-choro-4-fluoroanisole needs to pay attention to prevent fire and static electricity accumulation during use and storage to avoid fire or explosion.
2. Avoid contact with strong oxidants and strong bases to avoid hazardous substances.
3. After personal contact, rinse immediately with plenty of water and seek medical help.
4. 3-choro-4-fluoroanisole has certain toxicity to the environment, and attention should be paid to environmental protection during use.
Last Update：2024-04-09 19:05:47
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