2-chloro-3-fluoro-5-trifluoromethylpyridine

2-chloro-3-fluoro-5-trifluoromethylpyridine - Names and Identifiers

Name	Chloro-3-fluoro-5-(trifluoromethyl)pyridine
Synonyms	2-Chloro-3-fluoro-5-(trifluoromethyl) 2-chloro-3-fluoro-5-trifluoromethylpyridine Chloro-3-fluoro-5-(trifluoromethyl)pyridine 2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine 2-Chloro-3-fluoro-5-(trifluoromethyl)-pyridine Pyridine, 2-chloro-3-fluoro-5-(trifluoromethyl)- pyridine, 2-chloro-3-fluoro-5-(trifluoromethyl)-
CAS	72600-67-0
InChI	InChI=1S/C6H2ClF4N/c7-5-4(8)1-3(2-12-5)6(9,10)11/h1-2H

2-chloro-3-fluoro-5-trifluoromethylpyridine - Physico-chemical Properties

Molecular Formula	C6H2ClF4N
Molar Mass	199.53
Density	1.507±0.06 g/cm3(Predicted)
Boling Point	157.4±35.0 °C(Predicted)
pKa	-2.76±0.10(Predicted)
Storage Condition	2-8°C

2-chloro-3-fluoro-5-trifluoromethylpyridine - Risk and Safety

UN IDs	1993
Hazard Class	3
Packing Group	Ⅲ

2-chloro-3-fluoro-5-trifluoromethylpyridine - Introduction

Chloro-3-fluoro-5-(trifluoromethyl)pyridine is an organic compound with the chemical formula C6H2ClF4N. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless liquid
-Boiling Point: 135-137°C
-Melting point:-8°C
-Density: 1.62g/cm³
-Solubility: Soluble in organic solvents such as ether and chloroform

Use:
- Chloro-3-fluoro-5-(trifluoromethyl)pyridine are widely used in organic synthesis as intermediates for drugs and pesticides.
-It can be used to prepare pyrazole and chelating ligand compounds, and can be applied to the preparation of catalysts and catalysts for organic synthesis reactions.

Preparation Method:
- Chloro-3-fluoro-5-(trifluoromethyl) The synthesis of pyridine is mainly achieved by trifluoromethylated pyridine. In a specific step, trifluoromethylation may be accomplished by reacting trifluoroformic acid with phosphorus pentachloride in the presence of cuprous chloride.

Safety Information:
- Chloro-3-fluoro-5-(trifluoromethyl) The toxicity of pyridine has not been fully studied, but it can irritate the eyes and skin. Please pay attention to wear protective glasses and gloves when using, to ensure good ventilation around. Avoid direct contact with skin and inhalation of vapors. In case of contact, rinse with plenty of water and seek medical help. Store in a cool, dry place, away from fire and oxidizing agents.

Last Update：2024-04-09 15:17:59