2-chloro-5-(trifluoromethyl)pyrimidine

2-chloro-5-(trifluoromethyl)pyrimidine - Names and Identifiers

Name	2-chloro-5-(trifluoromethyl)pyrimidine
Synonyms	2-chloro-5-(trifluoromethyl)- (9CI) 2-Chloro-5-trifluoromethyl-pyrimidine 2-chloro-5-(trifluoromethyl)pyrimidine 2-Chloro-5-(trifluoromethyl)-1,3-diazine PyriMidine, 2-chloro-5-(trifluoroMethyl)- pyrimidine, 2-chloro-5-(trifluoromethyl)- Pyrimidine, 2-chloro-5-(trifluoromethyl)- (9CI)
CAS	69034-12-4
InChI	InChI=1/C5H2ClF3N2/c6-4-10-1-3(2-11-4)5(7,8)9/h1-2H
InChIKey	TYCYTQLXAIDJNF-UHFFFAOYSA-N

2-chloro-5-(trifluoromethyl)pyrimidine - Physico-chemical Properties

Molecular Formula	C5H2ClF3N2
Molar Mass	182.53
Density	1.504±0.06 g/cm3(Predicted)
Melting Point	48-52°C
Boling Point	222.1±35.0 °C(Predicted)
Flash Point	71℃
Vapor Presure	0.154mmHg at 25°C
pKa	-3.48±0.22(Predicted)
Storage Condition	-20°C
Refractive Index	1.445

2-chloro-5-(trifluoromethyl)pyrimidine - Risk and Safety

Risk Codes	R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	2811
WGK Germany	3
Hazard Class	6.1
Packing Group	Ⅲ

2-chloro-5-(trifluoromethyl)pyrimidine - Introduction

2-choro-5-(trifluoromethyl)pyrimidine is an organic compound with the chemical formula C5H2ClF3N2. It is a white crystalline powder, soluble in many organic solvents.

2-choro-5-(trifluoromethyl)pyrimidine is widely used in organic synthesis. It is an important intermediate in many drugs, pesticides and insecticides. It can be used for the synthesis of Legionella pneumophila inhibitors, virus inhibitors, anti-tumor drugs and other compounds.

A common method for preparing 2-chloro-5-(trifluoromethyl)pyrimidine is to react 2-chloro-5-nitropyrimidine with a trifluoromethyl compound. Among them, 2-chloro-5-nitropyrimidine can be generated by the reaction of pyrimidine and thionyl chloride, and then nitrated with sodium nitrite to obtain 2-chloro-5-nitropyrimidine.

For safety information, 2-chloro-5-(trifluoromethyl)pyrimidine should be operated in a well-ventilated area, wearing protective gloves and glasses if necessary. It is irritating, and contact with skin and eyes can cause irritation and burns. Care should be taken to avoid inhalation of its dust or solution vapors during use. If inhaled or ingested by mistake, seek medical attention immediately. Contact with strong oxidants and strong acids should be avoided during storage and handling.

Last Update：2024-04-09 20:02:46