2-chloro-5-ethylaminomethylpyridine

2-chloro-5-ethylaminomethylpyridine - Names and Identifiers

Name	2-chloro-5-ethylaminomethylpyridine
Synonyms	2-chloro-5-ethylaminomethylpyridine N-(6-Chloro-3-pyridylmethyl)ethanamine N-Ethyl(6-chloro-3-pyridyl)methylamine 6-CHLORO-N-ETHYL-3-PYRIDINEMETHANAMINE 3-Pyridinemethanamine, 6-chloro-N-ethyl- N-(6-Chloro-3-pyridylmethyl)-N-ethylamine N-[(6-Chloropyridin-3-yl)methyl]ethanamine
CAS	120739-77-7

2-chloro-5-ethylaminomethylpyridine - Physico-chemical Properties

Molecular Formula	C8H11ClN2
Molar Mass	170.64
Density	1.117
Boling Point	254℃
Flash Point	108℃
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Physical and Chemical Properties	This product is liquid, insoluble in water, soluble in toluene.

2-chloro-5-ethylaminomethylpyridine - Reference Information

Use

2-chloro-5-ethylaminomethylpyridine is an intermediate of the insecticide nenpyridine.

production method

the preparation method is as follows. Using 2-chloro-5-chloromethylpyridine as raw material, it reacts with ethylamine in a solvent to produce a product. Using 3-cyano-6-chloropyridine and ethylamine aqueous solution in an ethanol suspension with Rh/Al as the catalyst, hydrogen is passed at normal pressure. After the reaction, the catalyst is filtered to remove the catalyst, and the product is obtained by post-treatment. The toluene solution of acetaldehyde is added to the toluene solution of 5-chloromethyl-2-aminopyridine, the reaction temperature is 21~22 ℃, the reaction is stirred for 2h, then sodium borohydride is added in batches in the solution, the reaction is 3h, hydrochloric acid is added to adjust the pH = 7, the solvent is evaporated, the residue is added to alkali solution to adjust the pH = 11.5, and the product is extracted and concentrated with toluene.

Last Update：2024-04-09 20:52:54