2-chloro-6-(trifluoromethyl)pyridin-4-amine
2-chloro-6-(trifluoromethyl)pyridin-4-amine
CAS: 34486-22-1
Molecular Formula: C6H4ClF3N2
2-chloro-6-(trifluoromethyl)pyridin-4-amine - Names and Identifiers
2-chloro-6-(trifluoromethyl)pyridin-4-amine - Physico-chemical Properties
| Molecular Formula | C6H4ClF3N2 |
| Molar Mass | 196.56 |
| Density | 1.507 |
| Boling Point | 261℃ |
| Flash Point | 112℃ |
| Vapor Presure | 0.0118mmHg at 25°C |
| pKa | 0.30±0.50(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.501 |
2-chloro-6-(trifluoromethyl)pyridin-4-amine - Introduction
2-choro-6-(trifluoromethyl)pyridin-4-amine is an organic compound with the chemical formula C6H3ClF3N. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
-Appearance: colorless crystal
-Melting point: 95-98°C
-Boiling point: 220-225°C
-Density: 1.59g/cm³
-Soluble: Soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane
Use:
-2-choro-6-(trifluoromethyl)pyridin-4-amine is commonly used as an intermediate in organic synthesis and can be used to synthesize various nitrogen-containing compounds.
-It can be used to prepare pesticides, medicines and functional materials.
Preparation Method:
- 2-chloro-6-(trifluoromethyl)pyridin-4-amine can be obtained by the reaction of pyridine and trifluoromethyl chloride in the presence of hydrogen chloride. Pyridine is first dissolved in methanol or isopropanol, then trifluoromethyl chloride and hydrogen chloride are added, and the target product is obtained by high temperature reaction. After completion of the reaction, separation and purification are performed by crystallization or column chromatography.
Safety Information:
-2-choro-6-(trifluoromethyl)pyridin-4-amine is less toxic to humans under general conditions.
-Wear appropriate protective equipment such as gloves, goggles and overalls during operation.
-Avoid direct contact with skin and eyes, and ensure that the laboratory is well ventilated.
-Please follow the correct handling and storage methods to avoid contact with incompatible chemicals.
-Please strictly abide by relevant safety operation procedures during use.
Nature:
-Appearance: colorless crystal
-Melting point: 95-98°C
-Boiling point: 220-225°C
-Density: 1.59g/cm³
-Soluble: Soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane
Use:
-2-choro-6-(trifluoromethyl)pyridin-4-amine is commonly used as an intermediate in organic synthesis and can be used to synthesize various nitrogen-containing compounds.
-It can be used to prepare pesticides, medicines and functional materials.
Preparation Method:
- 2-chloro-6-(trifluoromethyl)pyridin-4-amine can be obtained by the reaction of pyridine and trifluoromethyl chloride in the presence of hydrogen chloride. Pyridine is first dissolved in methanol or isopropanol, then trifluoromethyl chloride and hydrogen chloride are added, and the target product is obtained by high temperature reaction. After completion of the reaction, separation and purification are performed by crystallization or column chromatography.
Safety Information:
-2-choro-6-(trifluoromethyl)pyridin-4-amine is less toxic to humans under general conditions.
-Wear appropriate protective equipment such as gloves, goggles and overalls during operation.
-Avoid direct contact with skin and eyes, and ensure that the laboratory is well ventilated.
-Please follow the correct handling and storage methods to avoid contact with incompatible chemicals.
-Please strictly abide by relevant safety operation procedures during use.
Last Update：2024-04-09 02:00:45
